A cross-sectional hospital-based study of autoantibody profile and clinical manifestations of systemic lupus erythematosus in south Indian patients.

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dc.contributor.authorKosaraju, K
dc.contributor.authorShenoy, S
dc.contributor.authorSuchithra, U
dc.date.accessioned2012-12-10T05:36:23Z
dc.date.available2012-12-10T05:36:23Z
dc.date.issued2010-07
dc.description.abstractOur study was aimed to analyze clinical manifestations, autoantibodies and other serological abnormalities in South Indian patients with systemic lupus erythematosus. Clinical history and findings on systemic examination were noted. Antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) were detected by immunofluorescence and ANA profile by Immunoblotting. Arthritis was most common followed by fever and skin rash. Clinical manifestations vary according to geographical location of the patient. ANA was positive in 64.28% and anti-dsDNA in 89.36% of patients. All patients with lupus nephritis were positive for dsDNA. Detection of antibodies to dsDNA, RNP and anti-Smith (Sm) are of diagnostic and prognostic importance.en_US
dc.identifier.citationKosaraju K, Shenoy S, Suchithra U. A cross-sectional hospital-based study of autoantibody profile and clinical manifestations of systemic lupus erythematosus in south Indian patients. Indian Journal of Medical Microbiology. 2010 Jul-Sept; 28(3): 245-247.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/143707
dc.language.isoenen_US
dc.source.urihttps://www.ijmm.org/article.asp?issn=0255-0857;year=2010;volume=28;issue=3;spage=245;epage=247;aulast=Kosarajuen_US
dc.subjectANA profileen_US
dc.subjectanti dsDNAen_US
dc.subjectantinuclear antibodiesen_US
dc.subjectsystemic lupus erythematosusen_US
dc.titleA cross-sectional hospital-based study of autoantibody profile and clinical manifestations of systemic lupus erythematosus in south Indian patients.en_US
dc.typeArticleen_US
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