Correlation between blood group and autoantibodies formation in multi-transfused thalassaemia patients

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dc.contributor.authorAl-Mamun, ABMen_US
dc.contributor.authorIslam, MAen_US
dc.contributor.authorFatema, Ken_US
dc.contributor.authorChakrabarty, Ten_US
dc.contributor.authorIslam, Ken_US
dc.contributor.authorKarim, TA.en_US
dc.date.accessioned2025-05-12T07:25:28Z
dc.date.available2025-05-12T07:25:28Z
dc.date.issued2024-10
dc.description.abstractBackground: Thalassemia is a prevalent genetic disorder of hemoglobin synthesis, characterized by reduced production or absence of one or more globin chains, requiring frequent blood transfusions that can lead to complications such as autoantibody formation. The purpose of this study was to assess the correlation between blood group and the formation of autoantibodies in thalassemia patients who have received multiple blood transfusions. Methods: This cross-sectional study at the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, conducted from October 2017 to September 2018, included 384 thalassemia patients who received at least 10 units of red cell concentrate. Participants were selected based on specific inclusion and exclusion criteria, with informed consent obtained. Data collection involved patient interviews, clinical examinations, and hematological tests. Statistical analysis using SPSS version 23.0 included Chi-square, Fisher抯 exact, and t-tests, with significance set at p<0.05. Results: Among 384 patients, the most common blood group was B+ (46.2%). Coombs' test results showed DCT positivity in 3.1% of 384 patients, ICT positivity in 7.5%, and both DCT and ICT in 4.2%. Most patients (92.3%) had their first transfusion after age 2, with 84.6% receiving transfusions every 2-4 weeks. Conclusions: In conclusion, B positive blood group thalassemia patients receiving frequent transfusions are at a higher risk of autoantibody formation, and Rhesus phenotype-matched blood with pre-storage leukodepletion is recommended to mitigate this risk.en_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, National Institute of Neurosciences and Hospital, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, Bangladeshen_US
dc.identifier.affiliationsDepartment of Transfusion Medicine, Dhaka Medical College Hospital, Dhaka, Bangladeshen_US
dc.identifier.citationAl-Mamun ABM, Islam MA, Fatema K, Chakrabarty T, Islam K, Karim TA.. Correlation between blood group and autoantibodies formation in multi-transfused thalassaemia patients . International Journal of Research in Medical Sciences. 2024 Oct; 12(10): 3656-3660en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/246840
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber10en_US
dc.relation.volume12en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20242923en_US
dc.subjectAlloimmunizationen_US
dc.subjectAutoantibodiesen_US
dc.subjectBlood transfusionen_US
dc.subjectBlood groupen_US
dc.subjectThalassemiaen_US
dc.titleCorrelation between blood group and autoantibodies formation in multi-transfused thalassaemia patientsen_US
dc.typeJournal Articleen_US
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