Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study.
dc.contributor.author | Surekha, D | en_US |
dc.contributor.author | Sailaja, K | en_US |
dc.contributor.author | Rao, D Nageswara | en_US |
dc.contributor.author | Padma, T | en_US |
dc.contributor.author | Raghunadharao, D | en_US |
dc.contributor.author | Vishnupriya, S | en_US |
dc.date.accessioned | 2009-01-07 | en_US |
dc.date.accessioned | 2009-05-29T05:02:27Z | |
dc.date.available | 2009-01-07 | en_US |
dc.date.available | 2009-05-29T05:02:27Z | |
dc.date.issued | 2009-01-07 | en_US |
dc.description.abstract | BACKGROUND: The Cytochrome P-4501A1 (CYP1A1) gene, located on chromosome 15q, is involved in the metabolism of carcinogens mainly polycyclic aromatic hydrocarbons as well as estrogen. It is considered as candidate gene for low-penetrance breast cancer susceptibility. Hence the present study aims to discuss the role of CYP1A1 polymorphisms in breast cancer. MATERIALS AND METHODS: A total of 250 breast cancer patients and the same number of healthy age-matched controls were analyzed for the polymorphism of CYP1A1*2 by polymerase chain reaction-restriction fragment length polymorphism. RESULTS: In the present study, association of CYP1A1*2 (Ile 462Val) polymorphism with breast cancer was studied. Only one breast cancer patient was observed to be homozygous for Val allele but none among controls. The frequency of heterozygous Ile/Val genotype was found to be increased significantly in breast cancer patients (68.1%) as compared to controls (51.0%). Higher frequency of heterozygotes for Val allele was observed among premenopausal breast cancer patients and patients with high BMI, positive for HER2/neu status and advanced stage of the disease in comparison to the corresponding groups. No significant association of CYP1A1*2 polymorphism was observed with occupation, estrogen receptor and progesterone receptor status of breast cancer patients. CONCLUSIONS: In conclusion, our results suggest a significant correlation between CYP1A1*2 expression and the occurrence of breast cancer. | en_US |
dc.description.affiliation | Department of Genetics, Osmania University, Hyderabad, India. | en_US |
dc.identifier.citation | Surekha D, Sailaja K, Rao DN, Padma T, Raghunadharao D, Vishnupriya S. Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. Indian Journal of Medical Sciences. 2009 Jan; 63(1): 13-20 | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/67183 | |
dc.language.iso | eng | en_US |
dc.source.uri | https://www.indianjmedsci.org | en_US |
dc.subject.mesh | Breast Neoplasms --genetics | |
dc.subject.mesh | Case-Control Studies | |
dc.subject.mesh | Cytochrome P-450 CYP1A2 --genetics | |
dc.subject.mesh | Female | |
dc.subject.mesh | Genetic Predisposition to Disease | |
dc.subject.mesh | Genotype | |
dc.subject.mesh | Humans | |
dc.subject.mesh | Polymorphism, Genetic | |
dc.subject.mesh | Receptors, Estrogen --genetics | |
dc.subject.mesh | Receptors, Progesterone --genetics | |
dc.subject.mesh | Risk Assessment | |
dc.title | Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study. | en_US |
dc.type | Journal Article | en_US |
dc.type | Research Support, Non-U.S. Gov't | en_US |
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