Correlation of prothrombin time and activated partial thromboplastin time with serum immunoglobulins in newly diagnosed patients with plasma cell dyscrasias: an experience from tertiary care centre

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dc.contributor.authorShafi, Filzaen_US
dc.contributor.authorGeelani, Sajaden_US
dc.contributor.authorRasool, Javiden_US
dc.contributor.authorKhan, Subuh Parvezen_US
dc.contributor.authorQadri, Syed Mudasiren_US
dc.contributor.authorBashir, Nusraten_US
dc.contributor.authorKhan, Fiza Parvezen_US
dc.date.accessioned2020-04-09T07:39:18Z
dc.date.available2020-04-09T07:39:18Z
dc.date.issued2018-03
dc.description.abstractBackground: Plasma cell dyscrasia (PCD) is the term used to describe the disorders characterized by neoplastic proliferation of plasma cells with the abnormal production of immunoglobulins (Ig). Patients with multiple myeloma frequently have abnormal coagulation tests. Aim of the present study were to correlate prothrombin time (PT) and Activated Partial Thromboplastin time (aPTT) with Ig concentrations in patients with newly diagnosed with PCD and to compare PT and aPTT values in untreated and treated patients diagnosed with PCDMethods: This study was conducted in the department of clinical hematology of SKIMS, a tertiary care hospital in northern India from 2015 to 2016. Patients diagnosed with PCD were advised for coagulogram (PT, aPTT) as a base line investigation. A total of 72 patients were included in the study.Results: 37% of multiple myeloma cases (newly diagnosed) and 22% of light chain disease patients presented with prolonged PT whereas none of the patients in treated cases of PCD had prolonged PT. The mean Ig concentration was significantly higher in patients with prolonged PT and aPTT compared to that of patients with normal PT and aPTT values. In IgA myeloma, the mean immunoglobulin concentration was 3643 mg/dL with a mean PT and aPTT values of 18.8s and 36.6 (p value: 0.006). The mean free light chain concentration in kappa (k) light chain myeloma was 1727 mg/L with a mean PT value of 20.5 s, mean aPTT value of 37.4 s (p-value: 0.026).Conclusions: Patients with newly diagnosed myeloma presented with prolonged PT as compared to the treated cases. Also, mean Ig concentration was significantly higher in patients with prolonged PT and aPTT compared to that of patients with normal PT and aPTT values.en_US
dc.identifier.affiliationsDepartment of Pathology and Immunohaematology, Government Medical College, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Clinical Haematology, Institute of Medical Sciences, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Internal Medicine, Institute of Medical Sciences, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Pathology, Sher e Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, Indiaen_US
dc.identifier.citationShafi Filza, Geelani Sajad, Rasool Javid, Khan Subuh Parvez, Qadri Syed Mudasir, Bashir Nusrat, Khan Fiza Parvez. Correlation of prothrombin time and activated partial thromboplastin time with serum immunoglobulins in newly diagnosed patients with plasma cell dyscrasias: an experience from tertiary care centre. International Journal of Advances in Medicine. 2018 Mar; 5(2): 419-423en_US
dc.identifier.issn2349-3925
dc.identifier.issn2349-3933
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/193935
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber2en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org/10.18203/2349-3933.ijam20181081en_US
dc.titleCorrelation of prothrombin time and activated partial thromboplastin time with serum immunoglobulins in newly diagnosed patients with plasma cell dyscrasias: an experience from tertiary care centreen_US
dc.typeJournal Articleen_US
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