Short term effect of diltiazem on portal hypertension in patients with non-cirrhotic portal fibrosis.

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dc.contributor.authorBanerjee, Sen_US
dc.contributor.authorBanerjee, S Sen_US
dc.contributor.authorChakraborty, Sen_US
dc.contributor.authorMukherjee, Pen_US
dc.date.accessioned1991-01-01en_US
dc.date.accessioned2009-05-29T02:23:32Z
dc.date.available1991-01-01en_US
dc.date.available2009-05-29T02:23:32Z
dc.date.issued1991-01-01en_US
dc.description.abstractFourteen patients of non-cirrhotic portal fibrosis (NCPF) with portal hypertension were put on oral diltiazem hydrochloride (90 mg/day) or placebo on a prospective, randomised, single blind basis for 15 days. Predrug hemodynamic and biochemical status were similar in both groups. Diltiazem produced significant reduction (p less than 0.001) in mean intrasplenic pressure: from 41.88 (SD +/- 6.18) to 21.5 (+/- 7.91) cm of normal saline as against 45.56 (+/- 9.45) to 43.33 (+/- 8.27) in the placebo group. Mean arterial pressure (MAP), heart rate and cardiac output (CO) did not change in either group. Thus, the calcium channel blocker diltiazem reduces portal pressure in patients with NCPF, independent of reduction in MAP and CO; this is advantageous in situations where compromised cardiac hemodynamics may prove deleterious.en_US
dc.description.affiliationDepartment of Medicine, Medical College Hospitals, Calcutta.en_US
dc.identifier.citationBanerjee S, Banerjee SS, Chakraborty S, Mukherjee P. Short term effect of diltiazem on portal hypertension in patients with non-cirrhotic portal fibrosis. Indian Journal of Gastroenterology. 1991 Jan; 10(1): 7-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/64085
dc.language.isoengen_US
dc.source.urihttps://www.indianjgastro.comen_US
dc.subject.meshAdulten_US
dc.subject.meshBlood Pressure --drug effectsen_US
dc.subject.meshDiltiazem --therapeutic useen_US
dc.subject.meshFibrosisen_US
dc.subject.meshHumansen_US
dc.subject.meshHypertension, Portal --drug therapyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPortal System --drug effectsen_US
dc.subject.meshProspective Studiesen_US
dc.titleShort term effect of diltiazem on portal hypertension in patients with non-cirrhotic portal fibrosis.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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