Autistic children exhibit distinct plasma amino acid profile.

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dc.contributor.authorNaushad, Shaik Mohammad
dc.contributor.authorJain, Jamal Md Nurul
dc.contributor.authorPrasad, Chintakindi Krishna
dc.contributor.authorNaik, Usha
dc.contributor.authorAkella, Radha Rama Devi
dc.date.accessioned2014-02-04T10:00:52Z
dc.date.available2014-02-04T10:00:52Z
dc.date.issued2013-10
dc.description.abstractIn order to ascertain whether autistic children display characteristic metabolic signatures that are of diagnostic value, plasma amino acid analyses were carried out on a cohort of 138 autistic children and 138 normal controls using reverse-phase HPLC. Pre-column derivatization of amino acids with phenyl isothiocyanate forms phenyl thio-carbamate derivates that have a λmax of 254 nm, enabling their detection using photodiode array. Autistic children showed elevated levels of glutamic acid (120 ± 89 vs. 83 ± 35 mmol/L) and asparagine (85 ± 37 vs. 47 ± 19 mmol/L); lower levels of phenylalanine (45 ± 20 vs. 59 ± 18 mmol/L), tryptophan (24 ± 11 vs. 41 ± 16 mmol/L), methionine (22 ± 9 vs. 28 ± 9 mmol/L) and histidine (45 ± 21 vs. 58 ± 15 mmol/L). A low molar ratio of (tryptophan/large neutral amino acids) × 100 was observed in autism (5.4 vs 9.2), indicating lesser availability of tryptophan for neurotransmitter serotonin synthesis. To conclude, elevated levels of excitatory amino acids (glutamate and asparagine), decreased essential amino acids (phenylalanine, tryptophan and methionine) and decreased precursors of neurotransmitters (tyrosine and tryptophan) are the distinct characteristics of plasma amino acid profile of autistic children. Thus, such metabolic signatures might be useful tools for early diagnosis of autism.en_US
dc.identifier.citationNaushad Shaik Mohammad, Jain Jamal Md Nurul, Prasad Chintakindi Krishna, Naik Usha, Akella Radha Rama Devi. Autistic children exhibit distinct plasma amino acid profile. Indian Journal of Biochemistry & Biophysics. 2013 Oct; 50(5): 474-478.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/150259
dc.language.isoenen_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/22649en_US
dc.subjectAutismen_US
dc.subjectGlutamateen_US
dc.subjectAsparagineen_US
dc.subjectTryptophanen_US
dc.subjectMethionineen_US
dc.subject.meshAmino Acids --blood
dc.subject.meshAmino Acids --deficiency
dc.subject.meshAutistic Disorder --blood
dc.subject.meshCase-Control Studies
dc.subject.meshChild
dc.subject.meshChild, Preschool
dc.subject.meshCohort Studies
dc.subject.meshFemale
dc.subject.meshGlutamine --blood
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMethionine --blood
dc.subject.meshNeurotransmitter Agents -blood
dc.subject.meshSample Size
dc.subject.meshTryptophan --blood
dc.titleAutistic children exhibit distinct plasma amino acid profile.en_US
dc.typeArticleen_US
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