Acquired drug resistance in tuberculosis in Harayana, India.

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dc.contributor.authorJanmeja, A Ken_US
dc.contributor.authorRaj, Ben_US
dc.date.accessioned1998-02-29en_US
dc.date.accessioned2009-05-30T21:12:16Z
dc.date.available1998-02-29en_US
dc.date.available2009-05-30T21:12:16Z
dc.date.issued1998-02-29en_US
dc.description.abstractSputa of 200 treatment failure cases of pulmonary tuberculosis over a period of 1991-1995 were subjected to culture and sensitivity testing against commonly used anti-tuberculosis drugs. Out of 200 cases, 75% revealed resistance to one or more anti-TB drugs, resistance to isoniazid was observed in 72% cases, it was 49% for rifampicin, and 37% for streptomycin, while the resistance rate for other drugs was low. Majority of patients had resistance to two or three drugs concomitantly while resistance to 4, 5 and 6 drugs was of very low order and resistance to reserved drugs like kanamycin, ethionamide and cycloserine was encountered infrequently (1%). Out of 200 treatment failure patients multidrug resistance (MDR) was seen in 59% cases as 16% revealed resistance to isoniazid alone and strains in 22% cases were sensitive to all drugs. The study concludes that acquired MDR against first line antituberculosis drugs had increased as significant resistance against 3 drug combinations was observed although resistance against 2 drugs concomitantly was insignificant. Most ominous acquired drug resistance was seen against rifampicin in our region. The trends of drug resistance in the country and Haryana State are compared and their implications on outcome of chemotherapy are discussed.en_US
dc.description.affiliationDepartment of Chest Tuberculosis, Pt Sharma PGIMS, Rohtak, India.en_US
dc.identifier.citationJanmeja AK, Raj B. Acquired drug resistance in tuberculosis in Harayana, India. Journal of the Association of Physicians of India. 1998 Feb; 46(2): 194-8en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/88406
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAntitubercular Agents --pharmacologyen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshDrug Resistance, Multipleen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshRisk Assessmenten_US
dc.subject.meshSputum --microbiologyen_US
dc.subject.meshTuberculosis, Multidrug-Resistant --drug therapyen_US
dc.titleAcquired drug resistance in tuberculosis in Harayana, India.en_US
dc.typeJournal Articleen_US
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