Identification of HLA-A24 restricted pre-erythrocytic stage specific T-cell epitopes using Plasmodium falciparum synthetic peptides: a preliminary study.

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dc.contributor.authorTippawangkosol, Pongsrien_US
dc.contributor.authorDuangchanda, Thitimonraten_US
dc.contributor.authorUbalee, Ratawanen_US
dc.contributor.authorRuengweerayut, Ronnatraien_US
dc.contributor.authorHirayama, Kenjien_US
dc.contributor.authorNa-Bangchang, Kesaraen_US
dc.date.accessioned2009-05-27T16:03:55Z
dc.date.available2009-05-27T16:03:55Z
dc.date.issued2009-01-28en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractFourteen (9 amino acids) peptides of Plasmodium falciparum pre-erythrocytic stage antigens, namely, TRAP, CTRP, LSA-1, STARP and MSP-1, restricted to HLA-A24 and specific to T-cell response were identified. The antigen-specific IFN-gamma responses of these synthetic peptides in malaria exposed and non-malaria exposed healthy adult volunteers were detected using the ex vivo ELISPOT assay. Five peptides from TRAP and CTRP antigens significantly increased IFN-y responses of 1/9 in malaria-exposed volunteers. There is no statistically significant difference in positive T-cell response induced by any peptides in malaria exposed volunteers when evaluated as a group. The frequency of expressed HLA-A24 in malaria-exposed and non-malaria-exposed healthy adults living in northwest and central Thailand was 90% (27/30) and 100% (12/12), respectively. Although no association between positive T-cell response and HLA-A24 was found, due to the low number of positive responders achieved, one positive responder in malaria- exposed group was presented as HLA-24.en_US
dc.description.affiliationDepartment of Parasitology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.en_US
dc.identifier.citationTippawangkosol P, Duangchanda T, Ubalee R, Ruengweerayut R, Hirayama K, Na-Bangchang K. Identification of HLA-A24 restricted pre-erythrocytic stage specific T-cell epitopes using Plasmodium falciparum synthetic peptides: a preliminary study. The Southeast Asian Journal of Tropical Medicine and Public Health. 2009 Jan; 40(1): 10-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/34332
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/2009-40-1/02-4370.pdfen_US
dc.titleIdentification of HLA-A24 restricted pre-erythrocytic stage specific T-cell epitopes using Plasmodium falciparum synthetic peptides: a preliminary study.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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Southeast Asian Journal of Tropical Medicine and Public Health