Silymarin ameliorates uterine and ovarian damage in streptozotocin induced diabetic rat model

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dc.contributor.authorYildirim, Nurien_US
dc.contributor.authorKose, Semiren_US
dc.contributor.authorYildirim, AlkimGulsahSahingozen_US
dc.contributor.authorSahin, Cagdasen_US
dc.contributor.authorYigitturk, Gurkanen_US
dc.contributor.authorYavasoglu, Altugen_US
dc.contributor.authorErbas, Oytunen_US
dc.date.accessioned2020-01-02T06:23:09Z
dc.date.available2020-01-02T06:23:09Z
dc.date.issued2018-04
dc.description.abstractDiabetes is a systemic disease that affects microvasculature in almost all organs. Uterus and the ovaries may also be a target for diabetes. We investigated effects of diabetes on the uterus and the ovaries and the role of silymarin treatment on the effects of diabetes on uterine and ovarian microenvironment in a diabetic rat model. Seven non-diabetic (control) and fourteen diabetic female mature Sprague-Dawley albino rats were used. Diabetes was induced by intraperitoneal injection of 60 mg/kg streptozotocin and 100 mg/kg oral silymarin and was administered for four weeks to 7 of diabetic rats. After the treatment, blood samples were collected; hysterectomy with bilateral oophorectomy was performed for histopathological examination. Stromal degeneration, follicular degeneration, stromal fibrosis scores of the ovary and gland degeneration and stromal fibrosis scores of endometrium were significantly decreased after silymarin treatment. Silymarin treatment significantly decreased plasma TGF-β levels and increased plasma AMH (Anti-Müllerian hormone) levels with respect to saline-treated group. This study suggests that silymarin ameliorates the uterine and ovarian damage in a diabetic rat model.en_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecologyen_US
dc.identifier.affiliationsDepartment of Histology and Embryology, Ege University, Izmir, Turkeyen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, DokuzEylul University, Izmir, Turkeyen_US
dc.identifier.affiliationsDepartment of Obstetrics and Gynecology, Tepecik Training and Research Hospital, Izmir, Turkeyen_US
dc.identifier.affiliationsDepartment of Physiology, Bilim University, Istanbul, Turkeyen_US
dc.identifier.citationYildirim Nuri, Kose Semir, Yildirim AlkimGulsahSahingoz, Sahin Cagdas, Yigitturk Gurkan, Yavasoglu Altug, Erbas Oytun. Silymarin ameliorates uterine and ovarian damage in streptozotocin induced diabetic rat model. Indian Journal of Biochemistry and Biophysics. 2018 Apr; 55(2): 137-142en_US
dc.identifier.issn0975-0959
dc.identifier.issn0301-1208
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/189988
dc.languageenen_US
dc.publisherNISCAIR-CSIR, Indiaen_US
dc.relation.issuenumber2en_US
dc.relation.volume55en_US
dc.source.urihttps://nopr.niscair.res.in/handle/123456789/44342en_US
dc.titleSilymarin ameliorates uterine and ovarian damage in streptozotocin induced diabetic rat modelen_US
dc.typeJournal Articleen_US
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