Anti-convulsivant and sedative like-effect of Abyssinone V-4’ methyl ether Isolated from Erythrina droogmansiana (Leguminosae).

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dc.contributor.authorEmmanuel, TALLA
dc.contributor.authorSidoine, NGATCHA
dc.contributor.authorJacqueline, NJAPDOUNKE
dc.contributor.authorGisèle, NKANTCHOUA
dc.contributor.authorGbaweng Abel Joël, YAYA
dc.contributor.authorElisabeth, NGO BUM
dc.contributor.authorJoseph, MBAFOR TANYI
dc.contributor.authorNicolas, NJINTANG YANOU
dc.date.accessioned2015-11-30T04:49:24Z
dc.date.available2015-11-30T04:49:24Z
dc.date.issued2015-10
dc.description.abstractErythrina droogmansiana is used in traditional medicine in Cameroon to treat epilepsy, insomnia and headaches. From this plant, many secondary metabolites are extracted including alcaloids, tannins, flavonoids, etc. Amongst the flavonoid, abyssinone V-4’ methyl ether is used in this manipulation. Animal models of epilepsy: pentylenetetrazol (PTZ), picrotoxine (PIC) and pilocarpine (PILO)-induced convulsions or turning behavior were used to evaluate anticonvulsant activity while diazepam-induced sleep test was used to evaluate sedative activity of the extract. Four doses of extracts were used for each group test (12.5, 25, 50 and 100 mg/kg). Abyssinone V-4' methyl ether protected 100% of mice against the convulsions induced by the pentylenetetrazole at the dose of 100 mg/kg. Abyssinone V-4’ methyl ether protected 100% of mice at the doses of 25 and 100 mg/kg and 80% at the doses of 12.5 and 50 mg/kg against generalized convulsions induced by picrotoxine. This flavonoid protected 100% of mice at the doses 25 and 50 mg/kg and 80% at the doses of 12.5 mg/kg against generalized convulsions induced by pilocarpine. Moreover, for the test of induction of convulsions by pilocarpine, Abyssinone V-4’ methyl ether protected 100% of mice at doses of 25 and 50 mg/kg and 71.43% at the doses of 12.5 and 100 mg/kg against death after 1h and 24h respectively. Abyssinone V-4’ methyl ether has anticonvulsivant properties and not sedative properties. These results explain the use of Erythrina droogmansiana to treat epilepsy.en_US
dc.identifier.citationEmmanuel TALLA, Sidoine NGATCHA, Jacqueline NJAPDOUNKE, Gisèle NKANTCHOUA, Gbaweng Abel Joël YAYA, Elisabeth NGO BUM, Joseph MBAFOR TANYI, Nicolas NJINTANG YANOU. Anti-convulsivant and sedative like-effect of Abyssinone V-4’ methyl ether Isolated from Erythrina droogmansiana (Leguminosae). Journal of Applied Pharmaceutical Science. 2015 Oct; 5(10): 1-5.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/166535
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=1643en_US
dc.subjectEpilepsyen_US
dc.subjectInsomniaen_US
dc.subjectTraditional medicineen_US
dc.subjectpilocarpineen_US
dc.subjectabyssinone V-4’ methyl etheren_US
dc.titleAnti-convulsivant and sedative like-effect of Abyssinone V-4’ methyl ether Isolated from Erythrina droogmansiana (Leguminosae).en_US
dc.typeArticleen_US
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