Assessment of Low Serum Uric Acid Level in Patients with Amyotrophic Lateral Sclerosis Evidence for Oxidative Stress

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dc.contributor.authorRaknuzzaman, Md.en_US
dc.contributor.authorIslam, Md. Rafiqulen_US
dc.contributor.authorJannaty, Tasnimen_US
dc.contributor.authorAhmed, Md. Anisen_US
dc.contributor.authorAbu, Shams Md. Hasan Ali Masumen_US
dc.contributor.authorAra, Kazi Jannaten_US
dc.date.accessioned2020-09-24T07:26:12Z
dc.date.available2020-09-24T07:26:12Z
dc.date.issued2019-09
dc.description.abstractBackground: The pathogenic mechanism of AmyotrophicLateral Sclerosis (ALS) remains indistinct. However, increasingevidence has indicated that uric acid (UA) may play aprotective role in the pathogenesis of ALS as well as in that ofother neurodegenerative diseases. Low serum uric acid (UA)levels are found in many neurodegenerative diseases. It hasbeen suggested that oxidative stress is one of the pathogenicmechanism for amyotrophic lateral sclerosis (ALS), and thusantioxidants such as UA that could reduce oxidative stressmight be beneficial in the early detection of progression of thedisease. The objective of this study was to prospectivelyinvestigate serum UA levels in ALS patients and to relate themto disease process and disease status.Methods: ALS patients and healthy controls who wereindividually well-matched for age, sex, and body mass index(BMI) underwent blood testing for serum UA levels, andanalyzed whether UA levels were correlated with the diseasestatus of the patients, severity of the disease as defined by theALS Functional Rating Scale-Revised (ALSFRS-R) andduration of illness.Results: The study included 37 ALS patients and 37 matchedcontrols. The serum UA level was lower in the ALS patients(4.29 mg/dl ±1.35 mg/dL, mean±SD) than in the controls (6.26mg/dL±1.22 mg/dL; p<0.001). Female ALS patients hadsignificantly lower (3.55 mg/dl± 0.89 mg/dL) than Male ALSpatients (4.53 mg/dl±1.4 mg/dL; p<0.05). Among the ALSpatients, the lower level of UA acid was strongly correlated withthe rate of disease progression (decrease in ALSFRS-R score)p<0.001. Uric acid level is inversely correlated with the durationof the disease (r -0.32). Respondents with smoking historygroup showed more likely to develop ALS than therespondents with no smoking history.Conclusion: ALS patients had lower serum UA levels than didhealthy individuals and it is significantly lower in Female ALSpatients than Male ALS patients. Uric acid levels in ALS werepositively correlated with the ALSFRS-R (severity) andnegatively associated with duration of illness. UA levels couldbe considered a biomarker of disease progression in the earlyphase in ALS patientsen_US
dc.identifier.affiliationsJunior Consultant, National Institute of Neurosciences & Hospital (NINS), Dhaka, Bangladesh.en_US
dc.identifier.affiliationsProfessor of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.en_US
dc.identifier.affiliationsDepartment of Biochemistry & Molecular biology, Dhaka University, Dhaka, Bangladesh.en_US
dc.identifier.affiliationsAssistant Professor of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.en_US
dc.identifier.affiliationsAssistant Professor of Neurology, Anwer Khan Modern Medical College, Dhaka, Bangladesh.en_US
dc.identifier.affiliationsDepartment of Neurology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh.en_US
dc.identifier.citationRaknuzzaman Md., Islam Md. Rafiqul, Jannaty Tasnim, Ahmed Md. Anis, Abu Shams Md. Hasan Ali Masum, Ara Kazi Jannat. Assessment of Low Serum Uric Acid Level in Patients with Amyotrophic Lateral Sclerosis Evidence for Oxidative Stress. International Journal of Medical Research Professionals. 2019 Sep; 5(5): 250-256en_US
dc.identifier.issn2454-6364
dc.identifier.issn2454-6356
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/203463
dc.languageenen_US
dc.publisherIbn Sina Academy of Medieval Medicine & Sciencesen_US
dc.relation.issuenumber5en_US
dc.relation.volume5en_US
dc.source.urihttps://dx.doi.org//10..21276/ijmrp.2019.5.5.056en_US
dc.subjectAmyotrophic Lateral Sclerosisen_US
dc.subjectSerum Uric Aciden_US
dc.subjectOxidative Stress.en_US
dc.titleAssessment of Low Serum Uric Acid Level in Patients with Amyotrophic Lateral Sclerosis Evidence for Oxidative Stressen_US
dc.typeJournal Articleen_US
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