Is the use of high-intensity atorvastatin associated with memory impairment?
dc.contributor.author | kidambi, Bharath raj | en_US |
dc.contributor.author | purohit, Vikas | en_US |
dc.contributor.author | Bajpai, Swati | en_US |
dc.contributor.author | Nehra, Ashima | en_US |
dc.contributor.author | Karthikeyan, Ganesan | en_US |
dc.date.accessioned | 2023-07-21T11:36:51Z | |
dc.date.available | 2023-07-21T11:36:51Z | |
dc.date.issued | 2022-02 | |
dc.description.abstract | High-intensity statins are the cornerstone of medical management in Acute Coronary Syndromes (ACS). However, their effect on neurocognition are less clear. In this prospective observational study, we gave guideline-directed high-intensity atorvastatin 40 mg to middle-aged statin-naïve ACS patients. Memory assessments were performed before and 6 months after statin therapy using 2 validated scales-the PostGraduate Institute Memory Scale (PGI-MS), and the Logical Memory Passage Test (LMPT). There was no significant difference in the mean PGI-MS test scores (baseline 75.4 ± 7.9, 6months 76.5 ± 8.2;p ¼ 0.26) or the overall composite scores (baseline 32.02 ± 3.2, 6months 32.8 ± 3.1; p ¼ 0.20), after 6 months of statin use. There was a small improvement in immediate recall (baseline score 8.5 ± 2.5, 6 months 9.04 ± 1.8; p ¼ 0.05), and delayed recall (baseline 6.1 ± 2.6, 6 months 6.9 ± 1.9, p ¼ 0.002). High-intensity atorvastatin use did not affect memory at 6 months among statin-naïve middle-aged patients with ACS. | en_US |
dc.identifier.affiliations | Department of Cardiology, SRM Medical College Hospital and Research Centre, Chennai, India | en_US |
dc.identifier.affiliations | Department of Cardiology, NIMS Medical College, Jaipur, India | en_US |
dc.identifier.affiliations | Geriatric Medicine, All India Institute of Medical Sciences, New Delhi, India | en_US |
dc.identifier.affiliations | Clinical Neuropsychology, All India Institute of Medical Sciences, New Delhi, India | en_US |
dc.identifier.affiliations | Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India | en_US |
dc.identifier.citation | kidambi Bharath raj, purohit Vikas, Bajpai Swati, Nehra Ashima, Karthikeyan Ganesan. Is the use of high-intensity atorvastatin associated with memory impairment?. Indian Heart Journal. 2022 Feb; 74(1): 66-68 | en_US |
dc.identifier.issn | 0019-4832 | |
dc.identifier.issn | 2213-3763 | |
dc.identifier.place | India | en_US |
dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/220869 | |
dc.language | en | en_US |
dc.publisher | Cardiological Society of India | en_US |
dc.relation.issuenumber | 1 | en_US |
dc.relation.volume | 74 | en_US |
dc.source.uri | https://doi.org/10.1016/j.ihj.2021.12.006 | en_US |
dc.subject | High-intensity statins | en_US |
dc.subject | Memory impairment | en_US |
dc.subject | Atorvastatin | en_US |
dc.subject | Memory loss | en_US |
dc.subject | Statin-induced memory impairment | en_US |
dc.title | Is the use of high-intensity atorvastatin associated with memory impairment? | en_US |
dc.type | Journal Article | en_US |
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