Is the use of high-intensity atorvastatin associated with memory impairment?

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dc.contributor.authorkidambi, Bharath rajen_US
dc.contributor.authorpurohit, Vikasen_US
dc.contributor.authorBajpai, Swatien_US
dc.contributor.authorNehra, Ashimaen_US
dc.contributor.authorKarthikeyan, Ganesanen_US
dc.date.accessioned2023-07-21T11:36:51Z
dc.date.available2023-07-21T11:36:51Z
dc.date.issued2022-02
dc.description.abstractHigh-intensity statins are the cornerstone of medical management in Acute Coronary Syndromes (ACS). However, their effect on neurocognition are less clear. In this prospective observational study, we gave guideline-directed high-intensity atorvastatin 40 mg to middle-aged statin-naïve ACS patients. Memory assessments were performed before and 6 months after statin therapy using 2 validated scales-the PostGraduate Institute Memory Scale (PGI-MS), and the Logical Memory Passage Test (LMPT). There was no significant difference in the mean PGI-MS test scores (baseline 75.4 ± 7.9, 6months 76.5 ± 8.2;p ¼ 0.26) or the overall composite scores (baseline 32.02 ± 3.2, 6months 32.8 ± 3.1; p ¼ 0.20), after 6 months of statin use. There was a small improvement in immediate recall (baseline score 8.5 ± 2.5, 6 months 9.04 ± 1.8; p ¼ 0.05), and delayed recall (baseline 6.1 ± 2.6, 6 months 6.9 ± 1.9, p ¼ 0.002). High-intensity atorvastatin use did not affect memory at 6 months among statin-naïve middle-aged patients with ACS.en_US
dc.identifier.affiliationsDepartment of Cardiology, SRM Medical College Hospital and Research Centre, Chennai, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, NIMS Medical College, Jaipur, Indiaen_US
dc.identifier.affiliationsGeriatric Medicine, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsClinical Neuropsychology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.affiliationsDepartment of Cardiology, All India Institute of Medical Sciences, New Delhi, Indiaen_US
dc.identifier.citationkidambi Bharath raj, purohit Vikas, Bajpai Swati, Nehra Ashima, Karthikeyan Ganesan. Is the use of high-intensity atorvastatin associated with memory impairment?. Indian Heart Journal. 2022 Feb; 74(1): 66-68en_US
dc.identifier.issn0019-4832
dc.identifier.issn2213-3763
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/220869
dc.languageenen_US
dc.publisherCardiological Society of Indiaen_US
dc.relation.issuenumber1en_US
dc.relation.volume74en_US
dc.source.urihttps://doi.org/10.1016/j.ihj.2021.12.006en_US
dc.subjectHigh-intensity statinsen_US
dc.subjectMemory impairmenten_US
dc.subjectAtorvastatinen_US
dc.subjectMemory lossen_US
dc.subjectStatin-induced memory impairmenten_US
dc.titleIs the use of high-intensity atorvastatin associated with memory impairment?en_US
dc.typeJournal Articleen_US
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