Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.

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dc.contributor.authorShah, Siddharth Nen_US
dc.contributor.author,en_US
dc.date.accessioned2003-09-09en_US
dc.date.accessioned2009-05-30T23:56:22Z
dc.date.available2003-09-09en_US
dc.date.available2009-05-30T23:56:22Z
dc.date.issued2003-09-09en_US
dc.description.abstractAIMS OF THE STUDY: Asthenic symptoms such as weakness accompany illness. This study investigates whether the centrally acting cholinergic agent, vitamin B analogue (sulbutiamine), is effective and acceptable in relieving these symptoms in infectious disease when combined with specific anti-infective treatment. METHODOLOGY: In a prospective uncontrolled, non-randomised, commercial, observational study, 1772 patients with an infectious disease and asthenic symptoms, drawn from the practice of 350 randomly selected physicians throughout India, received vitamin B analogue (sulbutiamine) in addition to specific anti-infective treatment for 15 days. The primary outcome variable was complete resolution of asthenic symptoms with treatment. RESULTS: The number (%, 95% confidence interval) of patients with complete resolution of all asthenic symptoms was 916 (51.7, 49.4-54). In the remaining patients, severe asthenia was reduced but persisted in 11 (0.6, 0-26); and moderate asthenia in 94 (5.3, 0-17.6). The response was greater in patients with acute infection and symptoms more related to cerebral function. Side effects occurred in 10 (0.6%), patients and well being improved significantly. CONCLUSIONS: Vitamin B analogue (sulbutiamine) may be a useful adjunct to specific anti-infective treatment.en_US
dc.description.affiliationSL Raheja Hospital, Bombay Mutual Terrace, Mumbai.en_US
dc.identifier.citationShah SN, . Adjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia. Journal of the Association of Physicians of India. 2003 Sep; 51(): 891-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/90867
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdulten_US
dc.subject.meshAsthenia --classificationen_US
dc.subject.meshConfidence Intervalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIndiaen_US
dc.subject.meshMaleen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshSeverity of Illness Indexen_US
dc.subject.meshThiamine --analogs & derivativesen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleAdjuvant role of vitamin B analogue (sulbutiamine) with anti-infective treatment in infection associated asthenia.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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