COMPARISON OF METHODS USED IN MEASURING NONADHERENCE AND THE BARRIERS AGAINST ADHERENCE TO ANTIPSYCHOTIC DRUGS IN OUTPATIENTS WITH SCHIZOPHRENIA
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2010-10-15
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Chiang Mai Medical Journal
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Background Methods Results Conclusion Chiang Mai Medical Journal 2010;49(3):97-103.Subjective methods such as self-reporting and psychiatrist rating might underestimatenonadherence to antipsychotic drugs. Objective methods such as the pill count should be added toevaluate nonadherence. Furthermore, barriers against adherence in Thailand may differ in someaspects from those in western countriesOf the 75 participants in the previous study, four were lost to follow-up. In this study theprevalence of nonadherence reported by the 71 remaining patients and psychiatrists was only 5.1%and 16.9%, respectively, while that measured by pill count was 46.5%. The three most commonbarriers reported by patients with schizophrenia were memory problems, stigma, and adverse drugreactions.A prospective study was conducted at Chiang Mai University Hospital, Thailand, in which75 patients with schizophrenia were followed up from a pervious study for three months to evaluatetheir adherence to antipsychotic drugs measured by self-reporting, psychiatrist rating and pill count.The nine domains of barriers against adherence were assessed, and risk factors associated with highbarriers were analyzed using the chi-square and independent t-tests.Although patient self-reporting was the method used most commonly to measureadherence to antipsychotic drugs in schizophrenia, it may underestimate the degree of nonadherence.In addition, little is known about barriers against adherence in patients with schizophrenia inThailand.
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Chiang Mai Medical Journal; Vol.49 No.3 September 2010 (pages 81 - 121); 97 - 103