NSAIDs and kidney.

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dc.contributor.authorEjaz, Pen_US
dc.contributor.authorBhojani, Ken_US
dc.contributor.authorJoshi, V Ren_US
dc.date.accessioned2004-08-26en_US
dc.date.accessioned2009-05-31T03:13:19Z
dc.date.available2004-08-26en_US
dc.date.available2009-05-31T03:13:19Z
dc.date.issued2004-08-26en_US
dc.description90 references.en_US
dc.description.abstractNSAIDs are commonly used drugs. Even with the advent of selective COX-2 inhibitors, nephrotoxicity still remains a concern. The adverse effects of NSAIDs are mediated via inhibition of prostaglandin synthesis from arachidonic acid by non-specific blocking of the enzyme cyclooxygenase leading to vasoconstriction and reversible mild renal impairment in volume contracted states. When unopposed, this may lead to acute tubular necrosis and acute renal failure. NSAIDs also produce interstitial nephritis with or without nephrotic syndrome secondary to minimal change disease. Although this presents as acute renal failure, it can progress in some cases to chronic renal failure. Papillary necrosis has been incriminated in the development of chronic renal failure secondary to NSAIDs. In patients on long term NSAIDs without acute or chronic renal failure, subclinical renal dysfunction such as reduced creatinine clearance and impaired urine concentrating ability has been shown to be present. Although this sub-clinical dysfunction is reversible on withdrawal of NSAIDs, some reports have suggested a persistent residual dysfunction. Even with a wide range of NSAIDs at our disposal, a renal safe NSAID is yet to be discovered.en_US
dc.description.affiliationPD Hinduja National Hospital and Medical Research Centre, Veer Savarkar Marg, Mahim, Mumbai.en_US
dc.identifier.citationEjaz P, Bhojani K, Joshi VR. NSAIDs and kidney. Journal of the Association of Physicians of India. 2004 Aug; 52(): 632-40en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/93716
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAnti-Inflammatory Agents, Non-Steroidal --adverse effectsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshKidney Failure, Acute --chemically induceden_US
dc.subject.meshKidney Failure, Chronic --chemically induceden_US
dc.subject.meshKidney Function Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshNephritis, Interstitial --chemically induceden_US
dc.subject.meshPrognosisen_US
dc.subject.meshRisk Assessmenten_US
dc.titleNSAIDs and kidney.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
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