Association of CYP2D6 (G1934A) gene and hematological disturbances in chronic pesticide exposures

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dc.contributor.authorSudjaroen, Yuttanaen_US
dc.contributor.authorPitaksilp, Tanunchanoken_US
dc.contributor.authorKampol, Ruchiwiten_US
dc.contributor.authorThongkao, Kanittadaen_US
dc.contributor.authorThongmuang, Pimpornen_US
dc.contributor.authorSuwannahong, Kowiten_US
dc.date.accessioned2020-10-16T08:56:42Z
dc.date.available2020-10-16T08:56:42Z
dc.date.issued2020-09
dc.description.abstractCytochrome P450 family genes (CYPs) have common polymorphisms, which are evaluated for pesticide-inducedoxidative stress susceptibility. Variant alleles in CYP enzymes may uncover susceptibility biomarkers of environmentaltoxicity. This study aims to investigate the relationship between CYP2D6 (G1934A) gene polymorphisms and chronicpesticide exposures, and to evaluate the association between CYP2D6 (G1934A) gene polymorphism on biochemicaland hematological parameters. A cross-sectional study was carried out at a health promoting hospital, Suphan Buri,Thailand. Rice farmers and a control group (n = 50 for each) were recruited and their personal data were collected. Theirblood samples were obtained by venepuncture and drawn into plain and Ethylenediaminetetraacetic acid (EDTA) tubes.Serum cholinesterase (SChE), liver function test, kidney function test, and complete blood count were assessed usingautomatic analyzers; and CYP2D6 (G1934A) genotyping was carried out by polymerase chain reaction-restrictionfragment length polymorphism (PCR-RFLP). SChE in rice farmers was significantly lower (p = 0.033), which maybe related to the use of chlorpyrifos. The genotypes were significantly different between rice farmers and the controlgroup (p = 0.0001), and the GA variant in rice farmers was more frequent. The CYP2D6 (G1934A) (rs 3892097))gene and SChE level were negatively correlated (r = −0.258, p = 0.009). However, other biochemical parameters werenot different. Blood indices, including mean corpuscular hemoglobin (MCH), mean corpuscular volume (MCV), andmean corpuscular hemoglobin concentration (MCHC), values of rice farmers were significantly lower than the controlgroup; and MCH, MCV, and MCHC values of the GA variant were also significantly lower than the wild type. The GAgenotype was associated with hematological toxicity of organophosphate metabolite in chronic exposures.en_US
dc.identifier.affiliationsDepartment of Applied Science, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok, Thailand.en_US
dc.identifier.affiliationsDepartment of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailanden_US
dc.identifier.affiliationsDepartment of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathumthani, Thailanden_US
dc.identifier.affiliationsDepartment of Applied Science, Faculty of Science and Technology, Suan Sunandha Rajabhat University, Bangkok, Thailanden_US
dc.identifier.affiliationsCollege of Allied Health Sciences, Suan Sunandha Rajabhat University, Samut Songkhram, Thailand.en_US
dc.identifier.affiliationsDepartment of Environmental Health, Faculty of Public Health, Burapha University, Chonburi, Thailanden_US
dc.identifier.citationSudjaroen Yuttana, Pitaksilp Tanunchanok, Kampol Ruchiwit, Thongkao Kanittada, Thongmuang Pimporn, Suwannahong Kowit. Association of CYP2D6 (G1934A) gene and hematological disturbances in chronic pesticide exposures. Journal of Applied Pharmaceutical Science. 2020 Sep; 2020 Sep: 065-071en_US
dc.identifier.issn2231-3354
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/210664
dc.languageenen_US
dc.publisherOpen Science Publishers LLPen_US
dc.relation.issuenumber9en_US
dc.relation.volume10en_US
dc.source.urihttps://dx.doi.org//10.7324/JAPS.2020.10908en_US
dc.subjectBlood indicesen_US
dc.subjectcholinesterase inhibitorsen_US
dc.subjectchronic pesticide exposureen_US
dc.subjectCYP2D6en_US
dc.subjectcytochrome P450en_US
dc.subjectorganophosphateen_US
dc.titleAssociation of CYP2D6 (G1934A) gene and hematological disturbances in chronic pesticide exposuresen_US
dc.typeJournal Articleen_US
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