Amelioration of Neuronal Deficits in Aged Rats Via Ganoderma lucidum Extract Alone and Combination with Alpha Lipoic Acid
No Thumbnail Available
Date
2025-03
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications India Pvt. Ltd.
Abstract
BackgroundAgeing is associated with progressive neuronal deficits, leading to cognitive decline and increased vulnerability to neurodegenerative diseases. Currently, there is no permanent treatment available which can cure ageing and associated neuronal deficits. ObjectivesThe purpose of this investigation was to examine the neuroprotective effects of Ganoderma lucidum extract (GLE), both alone and in combination with alpha lipoic acid (ALA), on age-related neuronal deficits in old rats. Materials and MethodsEight groups of rats were used in this investigation. GLE and ALA were administered alone and in combination for 90 days orally. After 90 days, various physiological, behavioural, oxidative stress and histopathological parameters were assessed. ResultsTreatment with GLE and ALA significantly and dose-dependently modulates the neuronal deficits of aged rats. GLE 100 with ALA 50 showed synergistic effects on aged rats. ConclusionNew recent data supports the benefits of GLE for cognitive deficits in aged rats.
Description
Keywords
Ganoderma lucidum extract, neuronal deficit, ageing
Citation
Kumar H, Bansal S, Chaudhary R, Sharma S, Gupta S, Choudhary S.. Amelioration of Neuronal Deficits in Aged Rats Via Ganoderma lucidum Extract Alone and Combination with Alpha Lipoic Acid. Journal of Pharmacology and Pharmacotherapeutics. 2025 Mar; 16(1): 77-91