Multiple courses of antenatal steroids.

Simple item page
dc.contributor.authorSandesh Kiran, P Sen_US
dc.contributor.authorDutta, Sourabhen_US
dc.contributor.authorNarang, Anilen_US
dc.contributor.authorBhansali, Anilen_US
dc.contributor.authorMalhi, Prahbhjoten_US
dc.date.accessioned2007-05-29en_US
dc.date.accessioned2009-05-30T16:28:18Z
dc.date.available2007-05-29en_US
dc.date.available2009-05-30T16:28:18Z
dc.date.issued2007-05-29en_US
dc.description.abstractThe benefits and risks of multiple courses of antenatal steroids (ANS) are still unresolved issues. This was a prospective cohort study in a level III neonatal unit. Preterm babies < or = 35 wk gestation were included. Malformations, chronic maternal steroid intake, exchange transfusions prior to cortisol sampling and incomplete ANS courses were exclusion criteria. Subjects were classified into: No course (Group 0), 1 course (group 1), 2 courses (Group 2), > 2 courses (Group 3) of antenatal dexamethasone. The key outcome was adrenal function assessed by basal and post-ACTH cortisol on day 3. Other outcomes were neonatal morbidity, mortality, growth parameters at birth, long term growth and neuro-development. Of 210 eligible babies, 124 were enrolled. 38, 51, 10 and 25 babies belonged to groups 0, 1, 2 and 3 respectively. Basal and post-ACTH serum cortisol did not show any significant difference between groups (p=0.5 and p=0.9 respectively). Incidence of severe HMD requiring ventilation was significantly lower (p=0.02) in multiple course group (combined groups 2 and 3) compared to single course group. There were no differences in other neonatal morbidity, birth OFC and weight between single and multiple ANS groups. Follow up data at a mean age of 22 mth was available in 59 subjects (69%) belonging to groups 1-3. No differences were noted in the proportion of patients with abnormal neurological examination (p=0.1), abnormal PDI (p=0.9), abnormal MDI (p=0.9) and physical growth between multiple and single course groups. Multiple courses of antenatal dexamethasone resulted in a significant decrease in severe forms of RDS and they did not cause adrenal suppression, decreased growth or impaired neuro-development.en_US
dc.description.affiliationDepartment of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.en_US
dc.identifier.citationSandesh Kiran PS, Dutta S, Narang A, Bhansali A, Malhi P. Multiple courses of antenatal steroids. Indian Journal of Pediatrics. 2007 May; 74(5): 463-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/84598
dc.language.isoengen_US
dc.source.urihttps://medind.nic.in/icb/icbai.shtmlen_US
dc.subject.meshAdrenal Glands --drug effectsen_US
dc.subject.meshChild Developmenten_US
dc.subject.meshDexamethasone --administration & dosageen_US
dc.subject.meshGlucocorticoids --administration & dosageen_US
dc.subject.meshHumansen_US
dc.subject.meshHydrocortisone --blooden_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshInfant, Prematureen_US
dc.subject.meshProspective Studiesen_US
dc.subject.meshRespiratory Distress Syndrome, Newborn --prevention & controlen_US
dc.titleMultiple courses of antenatal steroids.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Pediatrics