Plasma homocysteine levels in patients with coronary heart disease.

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dc.contributor.authorChacko, K Aen_US
dc.date.accessioned1998-05-01en_US
dc.date.accessioned2009-05-27T04:21:31Z
dc.date.available1998-05-01en_US
dc.date.available2009-05-27T04:21:31Z
dc.date.issued1998-05-01en_US
dc.description.abstractHyperhomocysteinemia is being identified as a risk factor for coronary heart disease but its role among Asian Indians has not been studied. This has practical importance because (1) the data generated in the West may not represent Indian population, and (2) the condition is remediable. To assess the magnitude of this problem, we studied 56 patients with coronary heart disease, and 53 control subjects. Details of diet, smoking, medication, hypertension and diabetes were recorded; lipids and sugar levels were estimated in all. Patients with renal and liver diseases were excluded. Serum homocysteine was estimated using liquid chromatography. Both the groups were comparable by age and sex. Higher, but statistically insignificant homocysteine levels were seen in patients with coronary heart disease: 10.98 +/- 9.04 nmol/ml vs 9.41 +/- 3.60 nmol/ml in control subjects. Among males, higher, but statistically insignificant levels were seen in coronary heart disease patients: 11.96 +/- 9.41 nmol/ml vs 9.87 +/- 3.50 nmol/ ml in control subjects; among females, the levels were lower though not significant: 5.10 +/- 1.64 nmol/ml vs 6.39 +/- 2.99 nmol/ml. Sub-group analysis with age 40 as dividing point did not show significant difference. Six (10.7%) patients with coronary heart disease and three (5.7%) control subjects had homocysteine levels above 95th percentile of control subjects (p = NS). Twenty-three (41.1%) coronary heart disease patients and 19 (35.9%) control subjects had levels above 10 nmol/ml (p = NS). We conclude that homocysteine is not a major risk factor for coronary heart disease in the study population. The lack of statistical significance could be due to inadequate sample size although some past studies reporting statistically significant association between coronary heart disease and homocysteine involved similar or smaller number of subjects. Larger studies are warranted to see if ethnic differences also have any role.en_US
dc.description.affiliationDepartment of Cardiology, Sree Sudheendra Medical Mission, Cochin.en_US
dc.identifier.citationChacko KA. Plasma homocysteine levels in patients with coronary heart disease. Indian Heart Journal. 1998 May-Jun; 50(3): 295-9en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4041
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAgeden_US
dc.subject.meshAngina, Unstable --blooden_US
dc.subject.meshChi-Square Distributionen_US
dc.subject.meshFemaleen_US
dc.subject.meshHomocysteine --blooden_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshMyocardial Infarction --blooden_US
dc.subject.meshRisk Factorsen_US
dc.subject.meshSex Characteristicsen_US
dc.subject.meshSurvival Rateen_US
dc.titlePlasma homocysteine levels in patients with coronary heart disease.en_US
dc.typeClinical Trialen_US
dc.typeControlled Clinical Trialen_US
dc.typeJournal Articleen_US
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