The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review

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dc.contributor.authorAyyanar, Pen_US
dc.contributor.authorSable, MNen_US
dc.contributor.authorAdhya, AKen_US
dc.contributor.authorDas, MKen_US
dc.contributor.authorKar, Men_US
dc.contributor.authorMishra, P.en_US
dc.date.accessioned2023-08-10T07:33:57Z
dc.date.available2023-08-10T07:33:57Z
dc.date.issued2023-09
dc.description.abstractAdrenocortical carcinoma (ACC) is a rare and aggressive malignancy. Extensive rhabdoid morphology in ACC has been described recently in very few cases. The proportion of rhabdoid morphology and the role of SMARCB1/ INI1 expression in these tumor cells to diagnose the specific variant is not described in the literature. We reviewed the clinicopathological features of nine cases of adrenocortical neoplasm. Out of which, three cases of ACC showed predominant rhabdoid morphology. Large discohesive cells with abundant cytoplasm containing eosinophilic inclusions, eccentric vesicular nucleus, and prominent nucleoli. INI1 immunostain was retained in all cases. We reported the rhabdoid variant of ACC, a novel entity, and its diagnostic approach from their histological mimickers. Identifying more cases of this entity will help to clearly understand the pathogenesis, biologic behaviour, and any specific molecular alterations in the future.en_US
dc.identifier.affiliationsDepartment of Pathology and Lab Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Urology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, Indiaen_US
dc.identifier.affiliationsDepartment of Surgical Oncology, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, Odisha, Indiaen_US
dc.identifier.citationAyyanar P, Sable MN, Adhya AK, Das MK, Kar M, Mishra P.. The rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature review. Indian Journal of Pathology & Microbiology. 2023 Sept; 66(3): 627-631en_US
dc.identifier.issn0377-4929
dc.identifier.issn0974-5130
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/223497
dc.languageenen_US
dc.publisherWolters Kluwer - Medknowen_US
dc.relation.issuenumber3en_US
dc.relation.volume66en_US
dc.source.urihttps://doi.org/10.4103/ijpm.ijpm_515_21en_US
dc.subjectAdrenocortical carcinomaen_US
dc.subjectINII1en_US
dc.subjectrhabdoid varianten_US
dc.subjectSMARCB1en_US
dc.titleThe rhabdoid variant of adrenocortical carcinoma-Report of three cases and literature reviewen_US
dc.typeJournal Articleen_US
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