Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.

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dc.contributor.authorLath, Ren_US
dc.contributor.authorChacko, Gen_US
dc.contributor.authorChandy, M Jen_US
dc.date.accessioned2001-06-12en_US
dc.date.accessioned2009-06-03T12:31:22Z
dc.date.available2001-06-12en_US
dc.date.available2009-06-03T12:31:22Z
dc.date.issued2001-06-12en_US
dc.description.abstractProliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.en_US
dc.description.affiliationDepartment of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India.en_US
dc.identifier.citationLath R, Chacko G, Chandy MJ. Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody. Neurology India. 2001 Jun; 49(2): 144-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/121610
dc.language.isoengen_US
dc.source.urihttps://neurologyindia.comen_US
dc.subject.meshAdenoma --diagnosisen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAntibodies, Monoclonalen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshKi-67 Antigen --metabolismen_US
dc.subject.meshMagnetic Resonance Imagingen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPituitary Neoplasms --diagnosisen_US
dc.titleDetermination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.en_US
dc.typeJournal Articleen_US
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