Thrombolytic therapy for prosthetic valve thrombosis in Third World countries.

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dc.contributor.authorAgrawal, Den_US
dc.contributor.authorDubey, Sen_US
dc.contributor.authorSaket, Ben_US
dc.contributor.authorBhargava, Men_US
dc.contributor.authorMehta, Nen_US
dc.contributor.authorLohchab, S Sen_US
dc.contributor.authorSatsangi, D Ken_US
dc.contributor.authorNigam, Men_US
dc.contributor.authorGupta, B Ken_US
dc.contributor.authorKhanna, S Ken_US
dc.date.accessioned1997-07-01en_US
dc.date.accessioned2009-05-27T04:21:48Z
dc.date.available1997-07-01en_US
dc.date.available2009-05-27T04:21:48Z
dc.date.issued1997-07-01en_US
dc.description.abstractIn order to clarify the role of thrombolytic therapy for treatment of prosthetic valve thrombosis, all cases admitted in the intensive care unit (ICU), between March 1987 and March 1997 with the diagnosis of prosthetic valve thrombosis and treated with streptokinase, were analysed. In total, 42 patients with clinical and echocardiographic evidence of left side tilting disc prosthetic valve thrombosis were treated. All the patients had only mitral valve prosthesis involvement. Streptokinase was administered as a bolus of 2.5 lac units over 30 minutes followed by 1 lac units/hour for 48-72 hours. Thirty-seven (88%) patients had successful thrombolysis. Overall mortality occurred in 9.5 percent patients due to systemic embolism and bleeding complications. Serial clinical, radiological and echocardiographic studies showed successful thrombolysis in 88 percent patients. This study demonstrates that streptokinase therapy is safe and effective first line treatment for left-sided prosthetic valve thrombosis and surgery should be reserved for those patients who fail to respond to thrombolytic therapy.en_US
dc.description.affiliationDepartment of Cardiothoracic Surgery and Cardiology, GB Pant Hospital, New Delhi.en_US
dc.identifier.citationAgrawal D, Dubey S, Saket B, Bhargava M, Mehta N, Lohchab SS, Satsangi DK, Nigam M, Gupta BK, Khanna SK. Thrombolytic therapy for prosthetic valve thrombosis in Third World countries. Indian Heart Journal. 1997 Jul-Aug; 49(4): 383-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/4113
dc.language.isoengen_US
dc.source.urihttps://indianheartjournal.comen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAge Distributionen_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshFemaleen_US
dc.subject.meshFibrinolytic Agents --therapeutic useen_US
dc.subject.meshHeart Valve Prosthesis Implantation --adverse effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSex Distributionen_US
dc.subject.meshStreptokinase --therapeutic useen_US
dc.subject.meshSurvival Rateen_US
dc.subject.meshThrombolytic Therapy --methodsen_US
dc.subject.meshThrombosis --drug therapyen_US
dc.titleThrombolytic therapy for prosthetic valve thrombosis in Third World countries.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
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