Acute histopathological changes induced by methyl isocyanate in lungs, liver, kidneys & spleen of rats.

Simple item page
dc.contributor.authorJeevaratnam, Ken_US
dc.contributor.authorSriramachari, Sen_US
dc.date.accessioned1994-05-01en_US
dc.date.accessioned2009-05-27T08:08:36Z
dc.date.available1994-05-01en_US
dc.date.available2009-05-27T08:08:36Z
dc.date.issued1994-05-01en_US
dc.description.abstractMethyl isocyanate (MIC), inhaled or administered subcutaneously (sc) at lethal concentration/dose caused essentially similar histopathological changes in all the viscera except for the lungs. The observed congestion of the viscera, foci of hepatocellular necrosis with widening of Disse's spaces in the liver and tubulo-rhexis with degeneration in the kidneys are attributable mostly to the initial shock. In addition, the lungs revealed more distinct route specific patterns of histopathological lesions. Inhaled MIC caused acute eosinophilic necrosis of the bronchial epithelium and frank alveolar edema, while MIC administered sc led to prominent vascular endothelial damage and severe interstitial pneumonitis with normal bronchial epithelium. The differential loci of damage in the lungs may be attributed to the immediate contact surface available for interaction with MIC.en_US
dc.description.affiliationDefence Research & Development Establishment, Gwalior.en_US
dc.identifier.citationJeevaratnam K, Sriramachari S. Acute histopathological changes induced by methyl isocyanate in lungs, liver, kidneys & spleen of rats. Indian Journal of Medical Research. 1994 May; 99(): 231-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/23389
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAnimalsen_US
dc.subject.meshIsocyanates --administration & dosageen_US
dc.subject.meshKidney --drug effectsen_US
dc.subject.meshLiver --drug effectsen_US
dc.subject.meshLung --drug effectsen_US
dc.subject.meshMaleen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Wistaren_US
dc.subject.meshSpleen --drug effectsen_US
dc.titleAcute histopathological changes induced by methyl isocyanate in lungs, liver, kidneys & spleen of rats.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research