Development and validation of RP-HPLC method for determination of Duloxetine hydrochloride in bulk and dosage form.

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dc.contributor.authorBhimanadhuni, Chusena Narasimharaju
dc.contributor.authorGarikapati, Devala Rao
dc.contributor.authorSrinivas, Chintha
dc.date.accessioned2014-07-19T07:53:05Z
dc.date.available2014-07-19T07:53:05Z
dc.date.issued2012-04
dc.description.abstractA reverse phase high performance liquid chromatographic method was developed for the determination of dulox-etine hydrochloride in bulk and dosage form. The separation was effected on a kromasil ODS C18 column (250mmX4.6mm, 5μ) using a mobile phase mixture of buffer and methanol in a ratio of 85:15 v/v at a flow rate of 1.0ml/min. The detection was made at 230nm. The retention time of duloxetine hydrochloride was found to be 3.443±0.06 min. Calibration curve was linear over the concentration range of 20-120μg/ml of duloxetine hydrochlo-ride. The propose method was validated as per the ICH guidelines. The method was accurate, precise, specific and rapid found to be suitable for the quantitative analysis of the drug and dosage form.en_US
dc.identifier.citationBhimanadhuni Chusena Narasimharaju, Garikapati Devala Rao, Srinivas Chintha. Development and validation of RP-HPLC method for determination of Duloxetine hydrochloride in bulk and dosage form. International Current Pharmaceutical Journal. 2012 Apr 1(5): 98-102.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/152831
dc.language.isoenen_US
dc.source.urihttps://www.icpjonline.com/documents/Vol1Issue5/02Abstract.htmen_US
dc.subjectMethod development and validationen_US
dc.subjectduloxetine hydrochlorideen_US
dc.subjectTabletsen_US
dc.subjectKromasil C18 columnen_US
dc.subjectRP-HPLCen_US
dc.titleDevelopment and validation of RP-HPLC method for determination of Duloxetine hydrochloride in bulk and dosage form.en_US
dc.typeArticleen_US
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