Antioxidants and lipid peroxidation in gestational diabetes--a preliminary study.

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dc.contributor.authorDey, Prasenjiten_US
dc.contributor.authorGupta, Preetien_US
dc.contributor.authorAcharya, Nimish Kumaren_US
dc.contributor.authorRao, Srinivasa Nageswaraen_US
dc.contributor.authorRay, Swagaten_US
dc.contributor.authorChakrabarty, Sanjibanen_US
dc.contributor.authorRamprasad, Sharanyaen_US
dc.contributor.authorKurian, Tina Annen_US
dc.contributor.authorMawroh, Anatolien_US
dc.contributor.authorKundu, Aishwaryaen_US
dc.contributor.authorBhaktha, Geethaen_US
dc.contributor.authorJoseph, Christy Philipen_US
dc.contributor.authorKumar, Pratapen_US
dc.contributor.authorRai, Lavanyaen_US
dc.contributor.authorRao, Anjalien_US
dc.date.accessioned2008-04-10en_US
dc.date.accessioned2009-06-01T08:12:01Z
dc.date.available2008-04-10en_US
dc.date.available2009-06-01T08:12:01Z
dc.date.issued2008-04-10en_US
dc.description.abstractIncreased free radical activity in gestational diabetes (GDM) can lead to a host of damaging and degenerative maternal and fetal complications. Hence antioxidant levels in blood of GDM mothers and cord blood were estimated. Erythrocyte glutathione (GSH), superoxide dismutase (SOD) and thiobarbituric acid reactive substances (TBARS), plasma vitamins C and E and serum total glutathione-S-transferase (GST), protein thiols and ceruloplasmin (Cp) were estimated spectrophotometrically in maternal blood of age matched controls and mothers with GDM and also in cord blood samples of the above. There was a significant increase in the erythrocytic GSH, serum total GST and protein thiols in GDM maternal blood when compared to controls whereas erythrocytic SOD exhibited a marked decrease in GDM cases. The changes in plasma vitamins C and E, Cp and erythrocytic TBARS in GDM were not significantly different from controls. Cord blood levels of protein thiols were also significantly increased in GDM. No significant changes were observed in the serum Cp and GST levels of the same. Hence, elevated glucose levels can induce oxidative stress in GDM mothers.en_US
dc.description.affiliationDepartment of Biochemistry, Kasturba Medical College and Hospital, Manipal 576 104.en_US
dc.identifier.citationDey P, Gupta P, Acharya NK, Rao SN, Ray S, Chakrabarty S, Ramprasad S, Kurian TA, Mawroh A, Kundu A, Bhaktha G, Joseph CP, Kumar P, Rai L, Rao A. Antioxidants and lipid peroxidation in gestational diabetes--a preliminary study. Indian Journal of Physiology and Pharmacology. 2008 Apr-Jun; 52(2): 149-56en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/108732
dc.language.isoengen_US
dc.source.urihttps://www.ijpp.comen_US
dc.subject.meshAdulten_US
dc.subject.meshAntioxidants --analysisen_US
dc.subject.meshBiological Markers --blooden_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshDiabetes, Gestational --blooden_US
dc.subject.meshFemaleen_US
dc.subject.meshFetal Blood --chemistryen_US
dc.subject.meshHumansen_US
dc.subject.meshLipid Peroxidationen_US
dc.subject.meshOxidative Stressen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshPregnancyen_US
dc.subject.meshYoung Adulten_US
dc.titleAntioxidants and lipid peroxidation in gestational diabetes--a preliminary study.en_US
dc.typeJournal Articleen_US
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