Anti-bacterial activity of neoandrographolide derivatives: In silico interaction with the bacterial target

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dc.contributor.authorSharma, Venuen_US
dc.contributor.authorSharma, Supriyaen_US
dc.contributor.authorMehra, Rukmankeshen_US
dc.contributor.authorK Kapoor, Kamalen_US
dc.contributor.authorK Dhar, Manojen_US
dc.contributor.authorKaul, Sanjanaen_US
dc.date.accessioned2023-08-09T06:01:39Z
dc.date.available2023-08-09T06:01:39Z
dc.date.issued2022-02
dc.description.abstractNatural products and their semi synthesized molecules have been used as efficient antibiotics since a long time. The present global health scenario has raised the demand for novel antimicrobial agents and drug targets that are effective against drug resistant pathogens, emerging infections etc. The current study has promoted the antibacterial activity of the glucoside labdane ‘neoandrographolide’, isolated from the methanolic extract of the medicinal plant Andrographis paniculata. Further modification at its glucoside hydroxyl groups to generate ester and acetonide derivatives was done and the antibacterial potential of these compounds was screened against common bacterial pathogens. Among various derivatives, 4?,6?-O-(4-methoxybenzylidene) neoandrographolide exhibited promising results. In addition, molecular modeling study of the active compound was also explored to identify its probable binding mode on the bacterial target. The present study reported antibacterial activity of neoandrographolide derivatives for first time and also the bioactive molecule, 4?,6?-O-(4-methoxybenzylidene) neoandrographolide was examined as a potent antibacterial agent against different strains.en_US
dc.identifier.affiliationsSchool of Biotechnologyen_US
dc.identifier.affiliationsIndian Institute of Integrative Medicines, Jammu-180 001, Jammu & Kashmir, Indiaen_US
dc.identifier.affiliationsDepartment of Chemistry, University of Jammu, Jammu 180 006, Jammu & Kashmir, Indiaen_US
dc.identifier.citationSharma Venu, Sharma Supriya, Mehra Rukmankesh, K Kapoor Kamal, K Dhar Manoj, Kaul Sanjana. Anti-bacterial activity of neoandrographolide derivatives: In silico interaction with the bacterial target. Indian Journal of Biochemistry & Biophysics. 2022 Feb; 59(2): 157-164en_US
dc.identifier.issn0019-5189
dc.identifier.issn0975-1009
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/221483
dc.languageenen_US
dc.publisherCSIR-NIScPRen_US
dc.relation.issuenumber2en_US
dc.relation.volume59en_US
dc.source.urihttps://doi.org/10.56042/ijbb.v59i2.42638en_US
dc.subjectAndrographis paniculataen_US
dc.subjectAntimicrobial activityen_US
dc.subjectLabdane diterpenesen_US
dc.subjectMolecular modelingen_US
dc.subjectSemi-synthetic derivativeen_US
dc.titleAnti-bacterial activity of neoandrographolide derivatives: In silico interaction with the bacterial targeten_US
dc.typeJournal Articleen_US
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