Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district
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Date
2024-02
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?Eldaghayes Publisher
Abstract
Background: Drug resistance tuberculosis (DRTB) is an important concern in India as it accounts, one-fourth of global burden. DRTB regimen is associated with adverse drug reactions (ADRs) accounting for significant mortality, non-adherence, and treatment discontinuation. Hence, the present study emphasis to be vigilant about these ADRs. Aims and Objectives: The aim of the study was to estimate the incidence, various types, and risk factors associated with adverse reactions in DRTB in Northern Karnataka district. Materials and Methods: A Prospective observational cohort study was conducted at Nodal DRTB center. All diagnosed and treatment initiated pulmonary DRTB patients during January–March 2021 aged ?18 years of either sex were included, which constituted 70 patients. A pre-designed case report form was used to collect details like sociodemographic information, past history, personal history, and drug regimen along with their contact information of the DRTB patients. Results: Of 70 study participants, 64% were males and mean age was 36.7 ± 14.5 years with majority being resistant to rifampicin (52%). Incidence of ADR was 32 (46%) and commonly reported ADR were nausea (30%), gastritis (24%), vomiting (21%), arthralgia (9%), and peripheral neuropathy (9%). Causality assessment was done using “Naranjo algorithm,” majority were probable (79.01%) and as per the modified Hartwig and Siegel severity scale most ADR were mild (87.65%). The past history of TB and exposure to ATT was the major risk factor associated and was statistically significant (P = 0.009). Conclusion: ADRs are common in DRTB regimen early recognition and appropriate management might determine treatment adherence, prevent complications, and improve overall treatment outcome.
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Keywords
Adverse Reactions Monitoring, Multidrug Resistance Tuberculosis, Risk Factors
Citation
Latha S, Somashekara SC, Ghatage S, Suraj B.. Adverse reaction monitoring in drug resistance tuberculosis patients in a Northern Karnataka district . National Journal of Physiology, Pharmacy and Pharmacology. 2024 Feb; 14(2): 339-343