Non-Starch Plant Polysaccharides: Physicochemical Modifications and Pharmaceutical Applications.

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dc.contributor.authorMajee, Sutapa Biswas
dc.contributor.authorAvlani, Dhruti
dc.contributor.authorBiswas, Gopa Roy
dc.date.accessioned2016-12-26T12:25:47Z
dc.date.available2016-12-26T12:25:47Z
dc.date.issued2016-10
dc.description.abstractPolysaccharides of natural, synthetic or semi-synthetic origin have been used from time immemorial in the development of drug delivery systems designed to achieve tailored and site-specific drug release. Starch-based polysaccharides derived from plants have been extensively studied in this regard. Natural polymeric excipients are preferred over their synthetic counterparts owing to their low cost, availability, biocompatibility, biodegradability and non-toxicity. The present review attempts to provide a new direction and a comprehensive insight on the physical properties, rheological behavior, toxicity profile, pharmaceutical applications, swelling behavior and drug diffusion kinetics from dosage forms based on non-starch polysaccharides of plant origin such as, psyllium, pectin, arabinoxylan, xyloglucan, guar gum galactomannan and konjac glucomannan. It has been observed from the current review that non-starch polysaccharides are safe for human consumption and can be successfully employed to deliver drugs specifically to stomach and colon in a sustained fashion. They have thus widened the scope of natural polymeric excipients and demand better industrial utilization on a commercial scale to minimize cost of production and to satisfy therapeutic needs in safe and effective manner.en_US
dc.identifier.citationMajee Sutapa Biswas , Avlani Dhruti, Biswas Gopa Roy. Non-Starch Plant Polysaccharides: Physicochemical Modifications and Pharmaceutical Applications. Journal of Applied Pharmaceutical Science. 2016 Oct; 6(10): 231-241.en_US
dc.identifier.issn2231-3354
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/180485
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/abstract.php?article_id=2039en_US
dc.subjectNon-starch polysaccharideen_US
dc.subjectpolymer blendingen_US
dc.subjectpolymer grafting. gastroretentiveen_US
dc.subjectmatrix tableten_US
dc.subjectmucoadhesive drug deliveryen_US
dc.subjectcolon-specific drug deliveryen_US
dc.titleNon-Starch Plant Polysaccharides: Physicochemical Modifications and Pharmaceutical Applications.en_US
dc.typeArticleen_US
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