Chloroquine and quinine resistant Plasmodium falciparum on the island of Mindoro, Philippines, 1982.

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dc.contributor.authorSmrkovski, L Len_US
dc.contributor.authorBuck, R Len_US
dc.contributor.authorRodriguez, C Sen_US
dc.contributor.authorWooster, M Ten_US
dc.contributor.authorMayuga, J Len_US
dc.contributor.authorRivera, Den_US
dc.date.accessioned2009-05-27T14:47:09Z
dc.date.available2009-05-27T14:47:09Z
dc.date.issued1982-12-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractA field study was conducted on the island of Mindoro, Republic of the Philippines in which over 800 persons were screened for malaria and approximately 8% were found positive. The in vitro microtechnique was used to test for sensitivity to chloroquine, amodiaquine, mefloquine and quinine in 20 slide-confirmed P. falciparum cases. Sixteen of these cases were also followed for in vivo chloroquine sensitivity. Four cases showed in vitro resistance to chloroquine; 2 also showed resistance to quinine. All showed in vitro sensitivity to mefloquine and amodiaquine. The results of in vivo test were consistent with either a sensitive (S) or R-1, resistant response to chloroquine. Taken together, the in vitro and in vivo chloroquine tests indicate 4 cases of chloroquine resistance at the R1 level.en_US
dc.identifier.citationSmrkovski LL, Buck RL, Rodriguez CS, Wooster MT, Mayuga JL, Rivera D. Chloroquine and quinine resistant Plasmodium falciparum on the island of Mindoro, Philippines, 1982. The Southeast Asian Journal of Tropical Medicine and Public Health. 1982 Dec; 13(4): 551-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31078
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshChloroquine --pharmacologyen_US
dc.subject.meshDrug Resistanceen_US
dc.subject.meshHumansen_US
dc.subject.meshPhilippinesen_US
dc.subject.meshPlasmodium falciparum --drug effectsen_US
dc.subject.meshQuinine --pharmacologyen_US
dc.titleChloroquine and quinine resistant Plasmodium falciparum on the island of Mindoro, Philippines, 1982.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
dc.typeResearch Support, U.S. Gov't, Non-P.H.S.en_US
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