Serological evaluation of leptospirosis in Hyderabad Andhra Pradesh: a retrospective hospital-based study.

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dc.contributor.authorVelineni, Sen_US
dc.contributor.authorAsuthkar, Sen_US
dc.contributor.authorUmabala, Pen_US
dc.contributor.authorLakshmi, Ven_US
dc.contributor.authorSritharan, Men_US
dc.date.accessioned2007-01-23en_US
dc.date.accessioned2009-05-28T09:21:43Z
dc.date.available2007-01-23en_US
dc.date.available2009-05-28T09:21:43Z
dc.date.issued2007-01-23en_US
dc.description.abstractPURPOSE: Leptospirosis is a zoonotic disease with humans getting the infection either from rodent hosts or from domestic animals. Urine contaminated environment is the common source of infection. This is an under-reported disease in Andhra Pradesh. We report a retrospective hospital-based study on 55 patients with suspected leptospirosis. METHODS: A total of 55 serum samples were collected from patients with suspected leptospirosis and subjected to serological testing by LeptoTek Dri-dot, microscopic agglutination test (MAT) and IgM enzyme-linked immunosorbent assay (ELISA). Identification of the predominant infecting serotype was done using a panel of 12 serovars. RESULTS: MAT analysis of all the 55 samples identified all cases to be positive. The predominant serogroup was Icterohaemorrhagiae (68%) followed by Australis (22%), Autumnalis (8%) and Javanica (2%). LeptoTek Dri-dot showed a sensitivity of 96% as compared to MAT. IgM ELISA done on 32 samples showed a sensitivity of 86.7% compared to MAT. CONCLUSIONS: MAT helped to identify Icterohemorrhagiae as the predominant serovar in this study. Despite the small number of samples analyzed, the data obtained establishes a need for a prospective study in this region.en_US
dc.description.affiliationDepartment of Animal Sciences, School of Life Sciences, University of Hyderabad, Hyderabad, India.en_US
dc.identifier.citationVelineni S, Asuthkar S, Umabala P, Lakshmi V, Sritharan M. Serological evaluation of leptospirosis in Hyderabad Andhra Pradesh: a retrospective hospital-based study. Indian Journal of Medical Microbiology. 2007 Jan; 25(1): 24-7en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/53812
dc.language.isoengen_US
dc.source.urihttps://www.ijmm.orgen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshHemagglutination Testsen_US
dc.subject.meshHospitalsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin M --immunologyen_US
dc.subject.meshIndiaen_US
dc.subject.meshLeptospira --growth & developmenten_US
dc.subject.meshLeptospirosis --blooden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshSerologic Testsen_US
dc.titleSerological evaluation of leptospirosis in Hyderabad Andhra Pradesh: a retrospective hospital-based study.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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