A survey of the potential clinical drug interactions between fluoxetine and co-prescribed

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dc.contributor.authorK Wiwattanawongsaen_US
dc.contributor.authorU Nualchanen_US
dc.contributor.authorO Kuelaoen_US
dc.contributor.authorS Thantasuwanen_US
dc.date.accessioned2011-02-22T06:20:05Z
dc.date.available2011-02-22T06:20:05Z
dc.date.created2009-12-25en_US
dc.date.issued2009-12-25en_US
dc.description.abstractObjective: To determine the prevalence of the potential interactions attributed to concomitant use of fluoxetine (FLX) with other therapeutic agents commonly prescribed at Songkhla Rajanagarindra Hospital.Method: Outpatient prescription data (June-August 2006) were retrospectively collected and analyzed. Information including patient's characteristics, number of events which FLX was co-prescribed with other drugs, dose and dosage regimen of FLX and those of the co-prescribed agents which can cause drug interactions (DIs) were recorded. The prevalence of potential DIs was reported as percentage and classified according to patient's age, gender, and significance level.Results: Sixty percent of 1,539 prescriptions containing FLX were likely to cause DIs. Thisnumber corresponded to 1,176 out of 1,802 pairs of FLX co-prescriptions. Dose of 20 mg/day was mostly prescribed for FLX, and patients aged 20-40 years old were mostly receiving FLX co prescription. Significance level 4 interactions were mostly characterized (45.2% of the potential DIs). Among the total of 15 drugs potentially causing DI with FLX, propranolol was the most frequently co-prescribed agent. Other agents found to be frequently co-prescribed with FLX were haloperidol, clozapine, tricyclic antidepressants, and anticonvulsants.Conclusion: Sixty percent of FLX co-prescription was likely to cause DI at Songkhla Rajanagarindra Hospital. Among the 15 identified agents potentially causing DI, frequently co-prescribed agents with FLX were propranolol, haloperidol, and clozapine.    en_US
dc.identifier.citationSongklanagarind Medical Journal; Vol. 27 No. 3 May-Jun 2009; 213-222en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/132114
dc.language.isoen_USen_US
dc.publisherSongklanagarind Medical Journalen_US
dc.rightsFaculty of Medicine, Prince of Songkla University, Songkla, Thailanden_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/SOMJ/issue/archiveen_US
dc.source.urihttps://thailand.digitaljournals.org/index.php/SOMJ/article/view/707en_US
dc.titleA survey of the potential clinical drug interactions between fluoxetine and co-prescribeden_US
dc.typeOriginal Articleen_US
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