Paper spacers coupled to metered dose inhalers in family practice.

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dc.contributor.authorSamaranayake, S Wen_US
dc.contributor.authorPerera, B Jen_US
dc.date.accessioned2009-05-28T05:01:11Z
dc.date.available2009-05-28T05:01:11Z
dc.date.issued1998-09-14en_US
dc.descriptionThe Ceylon Medical Journal.en_US
dc.description.abstractOBJECTIVES: 1. To assess the clinical efficacy of drug delivery using paper spacer devices coupled to metered dose inhalers (MDI). 2. To compare the effectiveness of paper spacers with the standard volumatic spacer. DESIGN: Randomised double-blind placebo controlled clinical trial. SETTING: Asthma clinic of a family practice at Kalutara. PATIENTS: 134 patients over 12 years of age, who attended the clinic with an acute episode of wheezing. METHOD: All patients over 12 years of age with an acute episode of wheezing who could speak a sentence of over 5 words were randomly allocated into 4 groups and administered salbutamol inhalations through a MDI coupled to a spacer. The first group used a 6-inch paper spacer, second group an 8-inch paper spacer, the third group a 10-inch paper spacer and the fourth group used a standard 750 ml volumatic spacer. MEASUREMENTS: In each subject, the peak expiratory flow rate (PFR) was recorded at the start, after placebo inhalation and after salbutamol inhalation. An increase of PFR of over 20% from the basal value was assessed as a good response. RESULTS: The number of patients who showed a good response after salbutamol inhalations in all four groups were very significant compared with the responses after placebo inhalations (p < 0.001). No significant differences were found in the effectiveness of salbutamol among the four other groups (p > 0.1). CONCLUSIONS: 1. All devices show equal efficacy. Metered dose inhalers and all 3 paper devices are as effective as the standard volumatic spacer. 2. The cost of a paper spacer device is negligible compared to that of the volumatic spacer. 3. The use of paper spacers in Sri Lankan family practices makes inhaled MDI therapy much cheaper without decreasing the effectiveness of drug delivery.en_US
dc.description.affiliationGeneral Hospital (Teaching), Colombo South.en_US
dc.identifier.citationSamaranayake SW, Perera BJ. Paper spacers coupled to metered dose inhalers in family practice. The Ceylon Medical Journal. 1998 Sep; 43(3): 147-50en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/47802
dc.language.isoengen_US
dc.source.urihttps://www.infolanka.com/CMJhome/en_US
dc.subject.meshAdministration, Inhalationen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAlbuterol --administration & dosageen_US
dc.subject.meshAsthma --drug therapyen_US
dc.subject.meshChilden_US
dc.subject.meshDeveloping Countriesen_US
dc.subject.meshDouble-Blind Methoden_US
dc.subject.meshEquipment Designen_US
dc.subject.meshFamily Practice --economicsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNebulizers and Vaporizers --economicsen_US
dc.subject.meshPeak Expiratory Flow Rate --drug effectsen_US
dc.subject.meshSri Lankaen_US
dc.titlePaper spacers coupled to metered dose inhalers in family practice.en_US
dc.typeClinical Trialen_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
dc.typeRandomized Controlled Trialen_US
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