Mortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India.

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dc.contributor.authorSobhani, Ramonaen_US
dc.contributor.authorBasavaraj, Anitaen_US
dc.contributor.authorGupta, Amitaen_US
dc.contributor.authorBhave, Ashok Sen_US
dc.contributor.authorKadam, Dilip Ben_US
dc.contributor.authorSangle, Shashikala Aen_US
dc.contributor.authorPrasad, Haridas Ben_US
dc.contributor.authorChoi, Jolineen_US
dc.contributor.authorJosephs, Joshuaen_US
dc.contributor.authorGebo, Kelly Aen_US
dc.contributor.authorMorde, Shweta Nen_US
dc.contributor.authorBollinger, Robert Cen_US
dc.contributor.authorKakrani, Arjun Len_US
dc.date.accessioned2007-08-13en_US
dc.date.accessioned2009-05-27T07:04:16Z
dc.date.available2007-08-13en_US
dc.date.available2009-05-27T07:04:16Z
dc.date.issued2007-08-13en_US
dc.description.abstractBACKGROUND & OBJECTIVE: In India, data regarding mortality and clinical characteristics of hospitalized HIV-infected patients are sparse, which may limit the effectiveness of new hospital-based HIV programmes providing antiretroviral therapy (ART). The objective of our study was to determine mortality and clinical characteristics of hospitalized HIV-infected individuals in a high HIV prevalence region of India. METHODS: A retrospective chart review was done of known HIV-infected adults admitted to the Medical Service of a large, public hospital in Pune, India, from January 2002 to November 2003. RESULTS: A total of 655 HIV-infected patients were identified; 489 (74.7%) were male and 4 (0.6%) were on ART. The most common illnesses reported were tuberculosis (55.8%), diarrhoea (4.2%), and alcoholic liver disease (3.7%) . The inpatient mortality was 172 (26.3%). The most common causes of death of the 172 people were tuberculosis (52.9%) and cryptococcal meningitis (7.6%). In multivariate analysis, factors associated with increased mortality were male sex (adjusted odds ratio (AOR) 1.92, 95% CI: 1.08-3.41), haemoglobin level < 7 g/dl (AOR 2.75, 95% CI:1.23-6.14), length of stay < 2 days (OR 5.78, 95%, CI: 1.82-18.4), and cryptococcal meningitis (OR 4.44, 95% CI:1.19-16.6). INTERPRETATION & CONCLUSION: In the era prior to widespread ART, a high inpatient mortality of 26 per cent was found among hospitalized HIV-infected individuals. Thus, while hospitalization is an important access and referral point for HIV care and treatment, earlier identification of HIV-infected persons must occur to ensure they will optimally benefit from the government's ART programme.en_US
dc.description.affiliationJohns Hopkins University School of Medicine, Baltimore, MD, USA.en_US
dc.identifier.citationSobhani R, Basavaraj A, Gupta A, Bhave AS, Kadam DB, Sangle SA, Prasad HB, Choi J, Josephs J, Gebo KA, Morde SN, Bollinger RC, Kakrani AL. Mortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India. Indian Journal of Medical Research. 2007 Aug; 126(2): 116-21en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/19173
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshAged, 80 and overen_US
dc.subject.meshAnti-Retroviral Agents --therapeutic useen_US
dc.subject.meshDiarrhea --complicationsen_US
dc.subject.meshFemaleen_US
dc.subject.meshHIV Infections --complicationsen_US
dc.subject.meshHospitalizationen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshLiver Diseases, Alcoholic --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMeningitis, Cryptococcal --complicationsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRetrospective Studiesen_US
dc.subject.meshTuberculosis --complicationsen_US
dc.titleMortality & clinical characteristics of hospitalized adult patients with HIV in Pune, India.en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, N.I.H., Extramuralen_US
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