Lead exposure and accumulation in healthy Thais: assessed by lead levels, EDTA mobilization and heme synthesis-related parameters.

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dc.contributor.authorWananukul, Wen_US
dc.contributor.authorSirivarasai, Jen_US
dc.contributor.authorSriapha, Cen_US
dc.contributor.authorChanatara, Ven_US
dc.contributor.authorChunvimaluang, Nen_US
dc.contributor.authorKeanpoompuang, Aen_US
dc.contributor.authorBoriboon, Wen_US
dc.contributor.authorPumala, Ken_US
dc.contributor.authorKaojarern, Sen_US
dc.date.accessioned2009-05-27T19:50:12Z
dc.date.available2009-05-27T19:50:12Z
dc.date.issued1998-02-08en_US
dc.descriptionChotmaihet Thangphaet.en_US
dc.description.abstractLead is one of the pollutants which is of public concern. The magnitude of lead contamination in Thai people is of interest. The objective of this study was to evaluate the lead status in normal healthy volunteers. Normal volunteers were included. The blood for lead level, Zinc protoporphyrin (ZPP), delta-aminolevulinic acid dehydratase (ALA-D) activity, and baseline urine for lead, delta-aminolevulinic acid (ALA) and coproporphyrinogen III (CP3) were collected. The EDTA mobilization test was done. 24 hour urine after administration of the drug was collected for lead analysis. Thirty volunteers were included in the study. All were men whose average age was 32.5 +/- 6.9 years. The mean lead level was 5.95 +/- 2.01 micrograms/dL and 5.83 +/- 2.32 micrograms/L in urine. The 24 hour urine lead contents before and after EDTA administration were significantly different (11.11 +/- 6.72 and 16.05 +/- 9.51 micrograms respectively). Blood ALA-D activity was 251.6 +/- 80.4 unit/ml of RBC. Urine ALA and CP3 were 0.56 +/- 1.2 mg/L and 22.17 +/- 23.9 micrograms/L respectively. All were in the normal ranges. All parameters suggested that the healthy Thai volunteers had an acceptable magnitude of lead exposure and accumulation.en_US
dc.description.affiliationDepartment of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok Thailand.en_US
dc.identifier.citationWananukul W, Sirivarasai J, Sriapha C, Chanatara V, Chunvimaluang N, Keanpoompuang A, Boriboon W, Pumala K, Kaojarern S. Lead exposure and accumulation in healthy Thais: assessed by lead levels, EDTA mobilization and heme synthesis-related parameters. Journal of the Medical Association of Thailand. 1998 Feb; 81(2): 110-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/41882
dc.language.isoengen_US
dc.source.urihttps://www.mat.or.th/journal/all.phpen_US
dc.subject.meshAdulten_US
dc.subject.meshCreatinine --analysisen_US
dc.subject.meshEdetic Acid --diagnostic useen_US
dc.subject.meshEnvironmental Exposure --adverse effectsen_US
dc.subject.meshEnvironmental Monitoringen_US
dc.subject.meshHeme --biosynthesisen_US
dc.subject.meshHumansen_US
dc.subject.meshLead --analysisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshReference Valuesen_US
dc.subject.meshThailanden_US
dc.subject.meshUrinalysisen_US
dc.titleLead exposure and accumulation in healthy Thais: assessed by lead levels, EDTA mobilization and heme synthesis-related parameters.en_US
dc.typeClinical Trialen_US
dc.typeJournal Articleen_US
dc.typeResearch Support, Non-U.S. Gov'ten_US
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