Soluble curcumin: A promising oral supplement for health management.
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Date
2011-04
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Abstract
Curcumin, the most active polyphenolic constituent of turmeric curcuminoids obtained from the
rhizome Curcuma longa, holds a high place in ayurvedic medicine but its role in conventional
disease management has also been established. However, it has poor bioavailability due to
insolubility in water becomes a limiting factor. Increasing its solubility followed by assessment of
effect of oral consumption of soluble curcumin on pathological parameters on healthy human
volunteers, sixteen healthy subjects comprising of nine females and seven males in the age group
of 24- 45 years, was undertaken. Oral administration was done in the form of 500 mg capsule,
twice a day, for 15 days. Complete blood profile, levels of blood glucose, lipid profile, renal
function tests and liver function tests were performed in subjects before the start and at the end of
the study. Soluble curcumin was found to improve the liver functions, kidney functions and
ameliorated the lipid profile, blood glucose in healthy volunteers, only in 15 days of oral
consumption. Enhanced bioavailability of soluble curcumin in the near future is likely to bring
this promising natural product to the forefront of therapeutic agents for treatment of human
diseases, especially age related problems.
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Keywords
Soluble curcumin, oral administration, blood glucose, lipid profile, bioavailability
Citation
Gandhi Puneet, Khan Zeba, Chakraverty Nivedita. Soluble curcumin: A promising oral supplement for health management. Journal of Applied Pharmaceutical Science. 2011 Apr; 1(2): 1-7.