The Power and Promise of Angiotensin Receptor Neprilysin Inhibitor (ARNI) in Heart Failure Management: National Consensus Statement

Chopra, H K; Wander, G S; Ponde, C K; Nanda, Navin C; Khullar, Dinesh; Venugopal, K; Ray, Saumitra; Nair, Tiny; Rana, D S; Kher, Vijay; Sawhney, J P S; Kasliwa, R R; Jabir, A; Chakraborty, Rabin; Chandra, Praveen; Bansal, Sandeep; Kumar, Viveka; Pancholia, A K; Kapoor, Aditya; Prakash, Sunil; Saxena, Anil; Rastogi, Vishal; Sharma, Vinod; Arora, Y K; Dasbiswas, Arup; Bhargava, Mohan; Jaswal, Aparna; Bhargava, K; Bhatia, Mona; Omar, A K; Khanna, N N; Passey, Rajiv; Bhalla, Dilip; Vijayalakshmi, I B; Bhalla, A K; Moorthy, Asha; Isser, H S; Mishra, S S; Routray, S N; Tandon, Vivek; Sinha, Ajay; Bansal, Manish; Jain, Praveen; Hotchandani, Ramesh; Jain, Dharmendra; Katyal, V K; Gulati, Sanjiv; Tandon, Rohit; Jaggi, Shalini; Sehgal, Blessy; Gupta, Vitull; Mehrotra, Rahul; Krishnamani, N C; Pathak, S N; Yadav, M S; Chawla, Rajeev; Pal, Jyotirmoy; Chatterjee, Nandini; Samajdar, Shambo, S; Shastry, N R.

The Power and Promise of Angiotensin Receptor Neprilysin Inhibitor (ARNI) in Heart Failure Management: National Consensus Statement

Date

2023-02

Authors

Chopra, H K

Wander, G S

Ponde, C K

Nanda, Navin C

Khullar, Dinesh

Venugopal, K

Ray, Saumitra

Nair, Tiny

Rana, D S

Kher, Vijay

Publisher

Association of Physicians of India

Abstract

Heart failure (HF) is a huge global public health task due to morbidity, mortality, disturbed quality of life, and major economic burden. It is an area of active research and newer treatment strategies are evolving. Recently angiotensin receptor-neprilysin inhibitor (ARNI), a class of drugs (the first agent in this class, Sacubitril–Valsartan), reduces cardiovascular mortality and morbidity in chronic HF patients with reduced left ventricular ejection fraction (LVEF). Positive therapeutic effects have led to a decrease in cardiovascular mortality and HF hospitalizations (HFH), with a favorable safety profile, and have been documented in several clinical studies with an unquestionable survival benefit with ARNI, Sacubitril–Valsartan. This consensus statement of the Indian group of experts in cardiology, nephrology, and diabetes provides a comprehensive review of the power and promise of ARNI in HF management and an evidence-based appraisal of the use of ARNI as an essential treatment strategy for HF patients in clinical practice. Consensus in this review favors an early utility of Sacubitril–Valsartan in patients with HF with reduced EF (HFrEF), regardless of the previous therapy being given. A lower rate of hospitalizations for HF with Sacubitril–Valsartan in HF patients with preserved EF who are phenotypically heterogeneous suggests possible benefits of ARNI in patients having 40–50% of LVEF, frequent subtle systolic dysfunction, and higher hospitalization risk.

Citation

Chopra H K, Wander G S, Ponde C K, Nanda Navin C, Khullar Dinesh, Venugopal K, Ray Saumitra, Nair Tiny, Rana D S, Kher Vijay, Sawhney J P S, Kasliwa R R, Jabir A, Chakraborty Rabin, Chandra Praveen, Bansal Sandeep, Kumar Viveka, Pancholia A K, Kapoor Aditya, Prakash Sunil, Saxena Anil, Rastogi Vishal, Sharma Vinod, Arora Y K, Dasbiswas Arup, Bhargava Mohan, Jaswal Aparna, Bhargava K, Bhatia Mona, Omar A K, Khanna N N, Passey Rajiv, Bhalla Dilip, Vijayalakshmi I B, Bhalla A K, Moorthy Asha, Isser H S, Mishra S S, Routray S N, Tandon Vivek, Sinha Ajay, Bansal Manish, Jain Praveen, Hotchandani Ramesh, Jain Dharmendra, Katyal V K, Gulati Sanjiv, Tandon Rohit, Jaggi Shalini, Sehgal Blessy, Gupta Vitull, Mehrotra Rahul, Krishnamani N C, Pathak S N, Yadav M S, Chawla Rajeev, Pal Jyotirmoy, Chatterjee Nandini, Samajdar Shambo S, Shastry N R.. The Power and Promise of Angiotensin Receptor Neprilysin Inhibitor (ARNI) in Heart Failure Management: National Consensus Statement. Journal of the Association of Physicians of India. 2023 Feb; 71(2): 70-77