Case report: Bilateral uveitis and papillitis secondary to treatment with pembrolizumab

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dc.contributor.authorNavarro-Perea, Cen_US
dc.contributor.authorGarcia-Gonzalez, Jen_US
dc.contributor.authorPerez-Blazquez, Een_US
dc.date.accessioned2020-04-10T02:05:34Z
dc.date.available2020-04-10T02:05:34Z
dc.date.issued2019-12
dc.description.abstractPembrolizumab is a programmed cell death protein 1 (PD-1) monoclonal antibody used in the treatment of metastatic melanomas. Severe ocular complications appear in less than 1% of the patients and require early treatment. We present the case of a patient diagnosed with a BRAF mutated metastatic melanoma. Ocular pain and a blurred vision appeared after treatment and the patient visited the ophthalmology emergency room, where he was diagnosed with acute anterior uveitis (AAU), synechiae, and bilateral papillitis. The patient was treated with topical corticosteroids, prednisone, and mydriatics, which immediately improved the patient's status. Therefore, when an ocular inflammatory disease exists, immune checkpoint inhibitor treatments must be ruled out as possible causes.en_US
dc.identifier.affiliationsDepartment of Ophthalmology, Hospital, Madrid, Spainen_US
dc.identifier.affiliationsDepartment of Rheumatology, Hospital, Madrid, Spainen_US
dc.identifier.citationNavarro-Perea C, Garcia-Gonzalez J, Perez-Blazquez E. Case report: Bilateral uveitis and papillitis secondary to treatment with pembrolizumab. Indian Journal of Ophthalmology. 2019 Dec; 67(12): 2075-2077en_US
dc.identifier.issn0301-4738
dc.identifier.issn1998-3689
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/197676
dc.languageenen_US
dc.publisherAll India Ophthalmological Societyen_US
dc.relation.issuenumber12en_US
dc.relation.volume67en_US
dc.source.urihttps://dx.doi.org/10.4103/ijo.IJO_1161_19en_US
dc.subjectCTLA-4en_US
dc.subjectmelanomaen_US
dc.subjectpapillitisen_US
dc.subjectPD-1en_US
dc.subjectpembrolizumaben_US
dc.subjectuveitisen_US
dc.titleCase report: Bilateral uveitis and papillitis secondary to treatment with pembrolizumaben_US
dc.typeJournal Articleen_US
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