Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients.
| dc.contributor.author | Singh, Deepak Kumar | |
| dc.contributor.author | Rastogi, Archana | |
| dc.contributor.author | Sakhuja, Puja | |
| dc.contributor.author | Gondal, Ranjana | |
| dc.contributor.author | Sarin, Shiv Kumar | |
| dc.date.accessioned | 2012-09-26T08:06:59Z | |
| dc.date.available | 2012-09-26T08:06:59Z | |
| dc.date.issued | 2010-07 | |
| dc.description.abstract | Background: Alcoholic steatohepatitis (ASH) and non-alcoholic steatohepatitis (NASH) are significant forms of liver disease and may progress to end-stage liver disease, cirrhosis and potentially malignant complications. The most difficult aspect of establishing a diagnosis of NASH is distinguishing it from ASH. Laboratory markers such as AST, ALT and GGT lack sufficient sensitivity and specificity. Aim: To study the clinical, biochemical and histological differences between non-alcoholic steatohepatitis (NASH) and alcoholic steatohepatitis (ASH). Materials and Methods: Sixty histologically confirmed cases of non-alcoholic steatohepatitis and 38 cases of alcoholic steatohepatitis were included in the study. A modified form of scoring system proposed by Yip and Burt was used to grade histological features of NASH and ASH. Results: Mean age was 42.85 ± 12.36 years in ASH group and 35.07 ± 8.06 years for NASH group. Male: Female ratio was 37:1 in ASH and 4:1 in NASH. The mean ALT (P = 0.012), SAP (P = 0.003), serum bilirubin (P = 0.001), AST/ALT ratio (P = 0.03), steatosis (P < 0.001), ballooning degeneration of hepatocytes (P < 0.001), portal inflammation (P < 0.001), Mallory hyaline (P = 0.001), ductular proliferation and fibrosis (P < 0.001) showed a significant difference between ASH and NASH cases. Discussion: Older age, male sex, larger derangement of serum biochemistry, high serum bilirubin, AST/ALT > 1, more ballooning degeneration, portal inflammation, Mallory's hyaline, hepatocytic and ductular cholestasis, ductular proliferation and higher stage of fibrosis favors a diagnosis of ASH. Younger age, high ALT, AST/ALT < 1, higher grade of steatosis and absence of extensive neutrophilic portal inflammation favors a diagnosis of NASH. | en_US |
| dc.identifier.citation | Singh Deepak Kumar, Rastogi Archana, Sakhuja Puja, Gondal Ranjana, Sarin Shiv Kumar. Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients. Indian Journal of Pathology & Microbiology. 2010 Jul-Sept; 53(3): 408-413. | en_US |
| dc.identifier.uri | https://imsear.searo.who.int/handle/123456789/141713 | |
| dc.language.iso | en | en_US |
| dc.source.uri | https://www.ijpmonline.org/article.asp?issn=0377-4929;year=2010;volume=53;issue=3;spage=408;epage=413;aulast=Singh | en_US |
| dc.subject | Alcoholic liver disease | en_US |
| dc.subject | alcoholic steatohepatitis | en_US |
| dc.subject | non-alcoholic | en_US |
| dc.title | Comparison of clinical, biochemical and histological features of alcoholic steatohepatitis and non-alcoholic steatohepatitis in Asian Indian patients. | en_US |
| dc.type | Article | en_US |