Clinical, endocrine and metabolic studies in the kindred of familial partial lipodystrophy--a syndrome of insulin resistance.

Simple item page
dc.contributor.authorVaidya, R Aen_US
dc.contributor.authorVaidya, A D Ben_US
dc.contributor.authorTalwalkar, S Cen_US
dc.contributor.authorMehtalia, S Den_US
dc.contributor.authorShringi, M Sen_US
dc.contributor.authorPandey, S Nen_US
dc.contributor.authorShah, S Jen_US
dc.contributor.authorGodse, Cen_US
dc.contributor.authorJoshi, J Ven_US
dc.contributor.authorSheth, Jen_US
dc.contributor.authorKamdar, V Ven_US
dc.date.accessioned2002-06-21en_US
dc.date.accessioned2009-05-30T22:12:51Z
dc.date.available2002-06-21en_US
dc.date.available2009-05-30T22:12:51Z
dc.date.issued2002-06-21en_US
dc.description.abstractOBJECTIVE: To study clinical, endocrine and metabolic profiles in the kindred of subjects with familial partial lipodystrophy (FPLD, Dunnigan type). MATERIAL AND METHODS: Twenty two relatives (10 males, 12 females), from an extended family with FPLD, were assessed for the phenotypic features, impaired glucose tolerance (IGT)/diabetes mellitus (DM), dyslipidemia and the presence of insulin resistance. Plasma glucose and serum lipids were measured using glucose oxidase and standard colorimetric methods. Serum insulin was estimated by radioimmunoassay. RESULTS: The age was 12 to 67 years, two being adolescents. Two of the 20 adults were overweight and eight were underweight; BMI (adults) was 15.5 to 28.5. Features of FPLD were evident among eight out of 12 women. This typical phenotype was not obvious in all 10 male members. Varying degree of Hirsuitism was observed in four of 12 women, acanthosis nigricans in 11 out of 22 members and skin tags were present in only eight of 22; hypertension in six members and diabetes in four. Eleven members had either impaired glucose tolerance (IGT) (n=7), or DM (n=4). Ten of 20 members showed hyperinsulinemic response on oral glucose tolerance test (OGTT). Dyslipidemia was present in 13 family members. CONCLUSION: The majority (2/3rd) of female members showed typical phenotypic features of FPLD, with a clustering of cardiovascular risk factors and insulin resistance syndrome. More than half the men without phenotypic features of FPLD had either IGT/DM, dyslipidemia, hypertension or cardiovascular disease.en_US
dc.description.affiliationBhavan's SPARC, JVPD Sheme, Mumbai.en_US
dc.identifier.citationVaidya RA, Vaidya AD, Talwalkar SC, Mehtalia SD, Shringi MS, Pandey SN, Shah SJ, Godse C, Joshi JV, Sheth J, Kamdar VV. Clinical, endocrine and metabolic studies in the kindred of familial partial lipodystrophy--a syndrome of insulin resistance. Journal of the Association of Physicians of India. 2002 Jun; 50(): 773-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/89321
dc.language.isoengen_US
dc.source.urihttps://www.japi.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshChilden_US
dc.subject.meshEndocrine Glands --metabolismen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshInsulin Resistance --geneticsen_US
dc.subject.meshLipodystrophy --complicationsen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshSyndromeen_US
dc.titleClinical, endocrine and metabolic studies in the kindred of familial partial lipodystrophy--a syndrome of insulin resistance.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Journal of the Association of Physicians of India