Is asparagine-linked protein glycosylation an obligatory requirement for angiogenesis?

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dc.contributor.authorBanerjee, D Ken_US
dc.contributor.authorVendrell-Ramos, Men_US
dc.date.accessioned1993-12-01en_US
dc.date.accessioned2009-05-27T09:26:28Z
dc.date.available1993-12-01en_US
dc.date.available2009-05-27T09:26:28Z
dc.date.issued1993-12-01en_US
dc.description.abstractDependence of protein N-glycosylation on capillary endothelial cell proliferation has been studied. Amphomycin, a potent N-glycosylation inhibitor, inhibited capillary endothelial cell proliferation in a dose-dependent manner. beta-Agonist isoproterenol as well as other intracellular cAMP enhancing agents, viz. cholera toxin, prostaglandin E1 and 8Br-cAMP, also enhanced capillary endothelial cell proliferation. In addition to cell proliferation, isoproterenol also enhanced protein glycosylation in these cells. Isoproterenol effect was mediated by beta-adrenoreceptors, as it got reduced on pre-treatment of cells with either atenolol or ICI 118, 551 or propranolol. Furthermore, isoproterenol stimulation of protein glycosylation by exogenous dolichyl monophosphate and its inhibition by tunicamycin (GlcNAc-1P transferase inhibitor) supported the concept that isoproterenol specifically stimulated protein N-glycosylation event(s) in the cell.en_US
dc.description.affiliationDepartment of Biochemistry, School of Medicine, University of Puerto Rico, San Juan 00936-5067.en_US
dc.identifier.citationBanerjee DK, Vendrell-Ramos M. Is asparagine-linked protein glycosylation an obligatory requirement for angiogenesis? Indian Journal of Biochemistry & Biophysics. 1993 Dec; 30(6): 389-94en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/27515
dc.language.isoengen_US
dc.source.urihttps://https://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb0.aspen_US
dc.subject.mesh8-Bromo Cyclic Adenosine Monophosphate --pharmacologyen_US
dc.subject.meshAdrenal Medulla --cytologyen_US
dc.subject.meshAdrenergic beta-Antagonists --pharmacologyen_US
dc.subject.meshAlprostadil --pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshAsparagineen_US
dc.subject.meshCattleen_US
dc.subject.meshCell Division --drug effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCholera Toxin --pharmacologyen_US
dc.subject.meshCyclic AMP --metabolismen_US
dc.subject.meshEndothelium, Vascular --cytologyen_US
dc.subject.meshGlycosylation --drug effectsen_US
dc.subject.meshIsoproterenol --pharmacologyen_US
dc.subject.meshLipopeptidesen_US
dc.subject.meshNeovascularization, Pathologicen_US
dc.subject.meshOligopeptides --pharmacologyen_US
dc.subject.meshProtein Processing, Post-Translational --drug effectsen_US
dc.titleIs asparagine-linked protein glycosylation an obligatory requirement for angiogenesis?en_US
dc.typeJournal Articleen_US
dc.typeResearch Support, U.S. Gov't, P.H.S.en_US
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