Salivary L-fucose as a biomarker for oral potentially malignant disorders and oral cancer

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dc.contributor.authorSharma, Muditaen_US
dc.contributor.authorSharma, Eklavyaen_US
dc.contributor.authorPrabhu, Vishnudasen_US
dc.contributor.authorPai, Vinitha Ramanathen_US
dc.contributor.authorD'souza, Jyothi MPen_US
dc.contributor.authorSindhu, Harishen_US
dc.contributor.authorJose, Majien_US
dc.date.accessioned2020-11-18T10:08:21Z
dc.date.available2020-11-18T10:08:21Z
dc.date.issued2020-07
dc.description.abstractBackground: The objective of this study was to evaluate the serum and salivary L-fucose in oral potentially malignant disorders (OPMDs) and oral cancer (OC) in order to investigate the possibility of using this as biomarker for early diagnosis. Materials and Methods: The study included 85 participants, who were grouped as control (30), OPMDs patients (25), and OC patients (30). Serum and unstimulated whole saliva were collected from participants of all groups and fucose estimation was done using spectrophotometry. The results were tabulated and analyzed statistically. Results: The mean serum L-fucose levels in normal, OPMDs, and OC group were 3.49, 19.18, and 35.75 mg/dl, respectively, while the levels of salivary L-fucose were 3.18, 7.02, and 11.66 mg/dl, respectively. A highly significant rise (P < 0.001) in serum and salivary L-fucose was observed in the study participants compared to control. Conclusions: The present study showed a significant and gradual increase in serum and salivary L-fucose from control to OPMDs to OC. From this study, we suggest that L-fucose can be used as a reliable biomarker and saliva can be used as a diagnostic fluid for screening and early detection of OCen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Geetanjali Dental and Research Institute, Geetanjali University, Udaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Oral and Maxillofacial Surgery, Geetanjali Dental and Research Institute, Geetanjali University, Udaipur, Rajasthan, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Yenepoya Medical College, Yenepoya University, Mangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, Andaman and Nicobar Islands, Indiaen_US
dc.identifier.affiliationsDepartment of Biochemistry, Kasturba Medical College, Mangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Oral Pathology and Microbiology, Yenepoya Dental College, Yenepoya University, Mangalore, Karnataka, Indiaen_US
dc.identifier.citationSharma Mudita, Sharma Eklavya, Prabhu Vishnudas, Pai Vinitha Ramanath, D'souza Jyothi MP, Sindhu Harish, Jose Maji. Salivary L-fucose as a biomarker for oral potentially malignant disorders and oral cancer. Journal of Cancer Research and Therapeutics. 2020 Jul; 16(3): 546-550en_US
dc.identifier.issn0973-1482
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/213857
dc.languageenen_US
dc.publisherWolters Kluwer India Pvt. Ltd.en_US
dc.relation.issuenumber3en_US
dc.relation.volume16en_US
dc.source.urihttps://dx.doi.org//10.4103/jcrt.JCRT_552_17en_US
dc.subjectL-fucoseen_US
dc.subjectoral canceren_US
dc.subjectoral potentially malignant disordersen_US
dc.subjectsalivaen_US
dc.subjectserumen_US
dc.titleSalivary L-fucose as a biomarker for oral potentially malignant disorders and oral canceren_US
dc.typeJournal Articleen_US
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