Comparison of clinical outcomes of conventional hemodialysis and online hemodiafiltration

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dc.contributor.authorMalik, M. S.en_US
dc.contributor.authorKhan, M. F.en_US
dc.contributor.authorBabu, K.en_US
dc.contributor.authorSiddini, V.en_US
dc.contributor.authorBallal, S.en_US
dc.date.accessioned2024-09-24T10:51:26Z
dc.date.available2024-09-24T10:51:26Z
dc.date.issued2023-08
dc.description.abstractBackground: Several studies have suggested that online hemodiafiltration (OL-HDF) may reduce the risk of mortality and improve quality of life of these patients compared with standard hemodialysis. Methods: Forty stable out patients on dialysis (20 patients on hemodialysis and 20 patients on online hemodiafiltration) above age of 18 years and dialysis vintage of more than 3 months were followed up for 18 months. Clinical, biochemical parameters of these patients along with the SF-36 score at baseline and after 18 months of follow up were assessed. Results: At 18 months, statistically significant difference was found between hemodialysis (HD) and OL- HDF groups in erythropoietin dose (p=0.047), urea reduction ratio (p=0.016), Kt/V (p=0.005), hemoglobin (p=0.043), serum albumin (p=0.002), phosphorus (p=0.024), parathyroid hormone (p=0.007), potassium (p=0.007), ?2 microglobulin (p=0.002), high sensitive c-reactive protein (p=0.037), and serum bicarbonate levels (p=0.022). We found statistically significant difference in intradialytic complications namely intradialytic hypotension, muscle cramps, simultaneous hypotension and muscle cramps and stoppage of dialysis. In terms of mortality, the difference was not statistically significant (p=0.052). Conclusions: Patients on OL- HDF were having better quality of life than patients on HD. Better solute clearance, anemia control, improved nutritional and Mineral bone disorder parameters were seen in OL-HDF. Less complications during dialysis were seen with OL-HDF. The difference in mortality rate between the HD group and OL- HDF group was not statistically significant.en_US
dc.identifier.affiliationsDepartment of Nephrology, Manipal Hospitals, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Manipal Hospitals, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Manipal Hospitals, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Manipal Hospitals, Bangalore, Karnataka, Indiaen_US
dc.identifier.affiliationsDepartment of Nephrology, Manipal Hospitals, Bangalore, Karnataka, Indiaen_US
dc.identifier.citationMalik M. S., Khan M. F., Babu K., Siddini V., Ballal S.. Comparison of clinical outcomes of conventional hemodialysis and online hemodiafiltration. International Journal of Research in Medical Sciences. 2023 Aug; 11(8): 2942-2949en_US
dc.identifier.issn2320-6071
dc.identifier.issn2320-6012
dc.identifier.placeIndiaen_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/234410
dc.languageenen_US
dc.publisherMedip Academyen_US
dc.relation.issuenumber8en_US
dc.relation.volume11en_US
dc.source.urihttps://doi.org/10.18203/2320-6012.ijrms20232426en_US
dc.subjectHemodiafiltrationen_US
dc.subjectHemodialysisen_US
dc.subjectOnlineen_US
dc.subjectOutcomeen_US
dc.titleComparison of clinical outcomes of conventional hemodialysis and online hemodiafiltrationen_US
dc.typeJournal Articleen_US
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