Study of hematopoietic progenitor cells in thalassemia after bone marrow transplantation.

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dc.contributor.authorTang-naitrisorana, Yen_US
dc.contributor.authorIssaragrisil, Sen_US
dc.contributor.authorVisuthisakchai, Sen_US
dc.contributor.authorSuvatte, Ven_US
dc.contributor.authorPiankijakum, Aen_US
dc.date.accessioned2009-05-27T15:02:39Z
dc.date.available2009-05-27T15:02:39Z
dc.date.issued1995-03-01en_US
dc.descriptionThe Southeast Asian Journal of Tropical Medicine and Public Health.en_US
dc.description.abstractThe hematopoietic committed progenitor cells (BFU-E and CFU-GM) in blood and bone marrow were studied in thalassemic patients before and after bone marrow transplantation. Eighteen transplants were performed in 17 patients with thalassemia. Five were homozygous beta-thalassemia and 12 were beta-thalassemia/hemoglobin E disease. The age ranged from 1.2-14 years (median = 3.4 years). The conditioning regimen comprised busulfan 3.5-4 mg/kg/day for 4 days and cyclophosphamide 50 mg/kg/day for 4 days. Cyclosporin in combination with methotrexate were administered post transplant for GVHD prophylaxis. Before transplantation, BFU-E and CFU-GM in the blood of the patients were significantly higher compared with normal (p < 0.05) but were normal in the bone marrow. Only the CFU-GM in the bone marrow of the successful cases after transplantation recovered to the normal level at the first month through the 12th month whereas the BFU-E were low. Both CFU-GM and BFU-E in the blood were lower than normal after follow up to the 12th month. Inspite of the low number of progenitor cells, there was hematological recovery in the blood of the patients. It may be due to the capacity of the hematopoiesis react to stress which could be amplified the differentiation compartment or the shortened-transit time through the stem cell compartment.en_US
dc.description.affiliationDepartment of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.en_US
dc.identifier.citationTang-naitrisorana Y, Issaragrisil S, Visuthisakchai S, Suvatte V, Piankijakum A. Study of hematopoietic progenitor cells in thalassemia after bone marrow transplantation. The Southeast Asian Journal of Tropical Medicine and Public Health. 1995 ; 26 Suppl 1(): 291-5en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/31766
dc.language.isoengen_US
dc.source.urihttps://www.tm.mahidol.ac.th/seameo/publication.htmen_US
dc.subject.meshBone Marrow --pathologyen_US
dc.subject.meshBone Marrow Transplantationen_US
dc.subject.meshBusulfan --therapeutic useen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshColony-Forming Units Assayen_US
dc.subject.meshCyclophosphamide --therapeutic useen_US
dc.subject.meshCyclosporine --therapeutic useen_US
dc.subject.meshFemaleen_US
dc.subject.meshGraft vs Host Disease --prevention & controlen_US
dc.subject.meshHematopoietic Stem Cells --pathologyen_US
dc.subject.meshHemoglobin Een_US
dc.subject.meshHemoglobinuria --pathologyen_US
dc.subject.meshHomozygoteen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunosuppressive Agents --therapeutic useen_US
dc.subject.meshInfanten_US
dc.subject.meshMaleen_US
dc.subject.meshMethotrexate --therapeutic useen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshbeta-Thalassemia --pathologyen_US
dc.titleStudy of hematopoietic progenitor cells in thalassemia after bone marrow transplantation.en_US
dc.typeComparative Studyen_US
dc.typeJournal Articleen_US
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