Platelet Distribution Width (PDW) - A Rarely Studied Platelet Indice for Determining the Causes of Thrombocytopenia.
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Date
2016-07
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Abstract
Background: Thrombocytopenia (TCP) is low platelets count, which is either due to defective platelet production or due
to increased platelet breakdown. The platelet number alone does not give a complete picture of platelet maturity and
function, therefore, the platelet indices have been the subject of intensive study in recent years, but they have not been
firmly established. Mean platelet volume (MPV) and platelet distribution width (PDW) are useful parameters in
evaluating disorders of platelets. This study was undertaken to evaluate the effectiveness of PDW in diagnosing causes
of thrombocytopenia. Methods: 510 cases of thrombocytopenia and 500 cases of Control group with normal platelet
count were included in the study. TCP was defined as platelet counts below 1.5 lacs/cumm. Hematological analysis was
done on Mindray BC-3000 plus automated hematology analyzer. All cases were reevaluated by peripheral smear
examination. Only those cases were included in the study, which showed platelet count and platelet volume parameters
with graph both in cases and in control group. Results: Hyper-destructive group constituted majority of the cases 352
(69%), while hypo-productive group and abnormal pooling constituted 30% and 1.42% cases respectively. The mean
PDW was significantly higher in hyper-destructive group when compared with hypo-productive group, Abnormal pooling
and control group. The difference was statistically significant. Conclusion: PDW provides plenty of clinical information
about the causes and patho-mechanisms of thrombocytopenia and could be helpful to distinguish hyper-destructive
thrombocytopenia from hypo-productive thrombocytopenia. More attention should be paid to PDW along with other
platelet indices to differentiate between hyper-destructive TCP from hypo-productive and abnormal pooling TCP.
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Keywords
Platelet distribution width (PDW), Platelet indices, Platelet volume parameters & Thrombocytopenia (TCP)
Citation
Khairkar Pritam Sewakdas, Pandey Ashish, More Sarika, Pandey Megha. Platelet Distribution Width (PDW) - A Rarely Studied Platelet Indice for Determining the Causes of Thrombocytopenia. Annals of International Medical and Dental Research. 2016 July-Aug; 2(4): 193-197.