Antibacterial activity of Eclipta alba (L.) Hassk.
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Date
2011-09
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Abstract
Eclipta alba (L.) Hassk is small branched annual herbaceous plant with a long
history of traditional medicines uses in many countries especially in tropical and subtropical
regions. The herb has been known for its curative properties and has been utilized as
antimytotoxic, analgesic, antibacterial, antihepatotoxic, antihaemorrhagic, antihyperglycemic,
antioxidant, immunomodulatory properties and it is considered as a good rejuvenator too. A
wide range of chemical compounds including coumestans, alkaloids, thiopenes, flavonoids,
polyacetylenes, triterpenes and their glycosides have been isolated from this species. Extracts
and metabolites from this plant have been known to possess pharmacological properties. The
present study confirmed the antibacterial potential of aerial parts extracts of Eclipta alba in
solvents like acetone, ethanol, methanol, aqueous and hexane against selected gram positive
and gram negative bacterial species. The antibacterial studies were done by agar well
diffusion methods. The MIC and MBC methods were also used. Hexane extract of showed
Eclipta alba high antibacterial activity against S.aureus, B.cereus, E.coli, S.typhi,
K.pneumoniae,S.pyogenes and P.aeruginosa. whereas acetone, ethanol, methanol and
aqueous extracts showed intermediate activity against S.aureus, B.cereus, E.coli, S.typhi,
K.pneumoniae, P.aeruginosa, P.mirabilis and S.pyogenes. The inhibitory activities of all the
extracts reported were compared with standard antibiotics (Ciprofloxacin 25 μg/ml). An MIC
of 90.0μg/ml shown by E.coli and S.aureus was considered to be the best (below 100μg/ml),
an MIC of 125.0μg/ml shown by E.coli, K.pneumoni, P.mirabilis and S.typhi was considered
to be better (100-500μg/ml) as such by the action of acetone, ethanol, methanol and hexane
extracts on test bacterial spp respectively MIC between (500-1000μg/ml) was considered to
be good. The aqueous extracts of Eclipta alba showed good activity against S.pyogenes,
B.cereus, E.coli and P.aeruginosa. If the dilution was above 1000μg/ml the extract were
considered inactive against S.aureus, K.pneumoniae, P.mirabilis and S.typhi. MBC results
were similar to MIC results but in the case of MBC the confirmation was made by absence of
growth in culture plates after 24 hrs of incubation at 37ºC. A potent antibacterial and
hepatoprotective drug could probably be formulated from the plant extract of Eclipta alba to
combat the effects of bacterial and hepatotoxic infections.
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Keywords
Salvia officinalis, anti-inflammatory, fractionated extracts, peritonitis
Citation
Pandey Manoj Kumar, Singh G N, Sharma Rajeev Kr, Lata Sneh. Antibacterial activity of Eclipta alba (L.) Hassk. Journal of Applied Pharmaceutical Science. 2011 Sept; 1(7): 104-107.