Diversity of Vibrio cholerae strains isolated in Delhi, India, during 1992-2000.

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dc.contributor.authorDas, Shuklaen_US
dc.contributor.authorGupta, Sunilen_US
dc.date.accessioned2005-03-12en_US
dc.date.accessioned2009-05-27T03:49:30Z
dc.date.available2005-03-12en_US
dc.date.available2009-05-27T03:49:30Z
dc.date.issued2005-03-12en_US
dc.descriptionJournal of Health, Population, and Nutrition.en_US
dc.description.abstractThe National Institute of Communicable Diseases (NICD), Delhi, India, conducts a laboratory-based surveillance of cholera cases referred from the Infectious Disease Hospital, Delhi. The prevalence and antimicrobial susceptibilities of Vibrio cholerae O1, O139, and others, isolated from cholera patients for nine years, were analyzed to determine the changing trends in their isolation and drug-resistance patterns. In total, 29,196 stool samples or rectal swabs, collected during April 1992-December 2000, were included in this study. Of these, 13,730 (47%) were positive for V. cholerae: 11,091 for V. cholerae O1 (80.7%) and 1,943 (14%) for V. cholerae O139, and 696 (5%) were non-O1 and non-O139. V. cholerae O1 was the dominant serotype during 1992-1993, when V. cholerae O139 emerged as a new serotype but, thereafter, remained low from 1994 to 1999. Phenotypically, re-emerged V. cholerae O139 in 2000 displayed a difference compared to those that appeared in 1992-1993, in that the current O139 strains were sensitive to co-trimoxazole. Resistance to nalidixic acid and furazolidone was constantly high (100%) among strains of V. cholerae O1 and O139. All strains of V. cholerae were uniformly susceptible to chloramphenicol, tetracycline, amikacin, and norfloxacin. Molecular studies revealed different clones of V. cholerae O1 and O139 prevailing in the country with the re-emergence of V. cholerae O139 of a different clonality in Delhi in 2000, which is likely to play a critical role in temporal antigenic variation among the serogroups of V. cholerae.en_US
dc.description.affiliationNational Institute of Communicable Diseases, 22 Sham Nath Marg, Delhi 110 054, India. shukladas_123@yahoo.comen_US
dc.identifier.citationDas S, Gupta S. Diversity of Vibrio cholerae strains isolated in Delhi, India, during 1992-2000. Journal of Health, Population, and Nutrition. 2005 Mar; 23(1): 44-51en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/532
dc.language.isoengen_US
dc.source.urihttps://www.icddrb.org/pub/publication.jsp?classificationID=30&typeClassificationID=2en_US
dc.source.urihttps://www.icddrb.org/publication.cfm?classificationID=30&pubID=6007en_US
dc.subject.meshAnti-Bacterial Agents --pharmacologyen_US
dc.subject.meshBacteriophage Typingen_US
dc.subject.meshCholera --drug therapyen_US
dc.subject.meshDrug Resistance, Bacterialen_US
dc.subject.meshElectrophoresis, Gel, Pulsed-Fielden_US
dc.subject.meshFeces --microbiologyen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHumansen_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMicrobial Sensitivity Testsen_US
dc.subject.meshSeasonsen_US
dc.subject.meshSerotypingen_US
dc.subject.meshVibrio cholerae --classificationen_US
dc.titleDiversity of Vibrio cholerae strains isolated in Delhi, India, during 1992-2000.en_US
dc.typeJournal Articleen_US
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