Dubin-Johnson syndrome--a clinicopathologic study of twenty cases.

Simple item page
dc.contributor.authorRastogi, Archanaen_US
dc.contributor.authorKrishnani, Narendraen_US
dc.contributor.authorPandey, Rakeshen_US
dc.date.accessioned2006-10-23en_US
dc.date.accessioned2009-05-29T11:06:38Z
dc.date.available2006-10-23en_US
dc.date.available2009-05-29T11:06:38Z
dc.date.issued2006-10-23en_US
dc.description23 references.en_US
dc.description.abstractDubin-Johnson syndrome (DJS) is a rare benign chronic disorder of bilirubin metabolism, characterized by conjugated hyperbilirubinemia, darkly pigmented liver and presence of abnormal pigment in hepatic parenchymal cells. This is a retrospective study of twenty cases of DJS highlighting their major clinical and pathological findings. Liver biopsies were available in all the cases, obtained during a fourteen-year period (January 1991 to March 2005). The patients' age ranged from 7-63 years (median 21 years). These twenty cases comprised 13 males and 7 females. Major clinical manifestations were recurrent or persistent jaundice, abdominal pain and fever. Duration of illness ranged from 9 months to 58 years (median 10 years). All of them had conjugated hyberbilirubinemia and total serum bilirubin levels ranged between 1.4-13 mg/dl (mean 4.4 mg/dl). Liver biopsies revealed presence of coarse granular brown pigment in the cytoplasm of hepatocytes more concentrated in the pericanalicular region and more prominent in centrilobular hepatocytes. Associated findings were presence of hepatitis B virus related chronic hepatitis (1), history of tubercular lymphadenitis (1), chronic cholecystitis in (2), coronary heart disease (1) and exacerbation during pregnancy (1).en_US
dc.description.affiliationDepartment of Pathology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, PIN 226014.en_US
dc.identifier.citationRastogi A, Krishnani N, Pandey R. Dubin-Johnson syndrome--a clinicopathologic study of twenty cases. Indian Journal of Pathology & Microbiology. 2006 Oct; 49(4): 500-4en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/73160
dc.language.isoengen_US
dc.source.urihttps://www.ijpmonline.orgen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshBiopsyen_US
dc.subject.meshChilden_US
dc.subject.meshFemaleen_US
dc.subject.meshHepatocytes --metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshHyperbilirubinemiaen_US
dc.subject.meshJaundice, Chronic Idiopathic --pathologyen_US
dc.subject.meshLiver --pathologyen_US
dc.subject.meshLiver Diseases --pathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshPigmentationen_US
dc.titleDubin-Johnson syndrome--a clinicopathologic study of twenty cases.en_US
dc.typeCase Reportsen_US
dc.typeJournal Articleen_US
dc.typeReviewen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Pathology & Microbiology