Detection of virus specific IgG subclasses in Japanese encephalitis patients.

Simple item page
dc.contributor.authorThakare, J Pen_US
dc.contributor.authorGore, M Men_US
dc.contributor.authorRisbud, A Ren_US
dc.contributor.authorBanerjee, Ken_US
dc.contributor.authorGhosh, S Nen_US
dc.date.accessioned1991-09-01en_US
dc.date.accessioned2009-05-27T07:25:46Z
dc.date.available1991-09-01en_US
dc.date.available2009-05-27T07:25:46Z
dc.date.issued1991-09-01en_US
dc.description.abstractDuring the Japanese encephalitis (JE) epidemic in 1988 at Gorakhpur, Uttar Pradesh, 34 cerebrospinal fluid (CSF) samples with 16 matching sera from 34 anti JEV IgM positive (confirmed JE) and 24 CSF samples with 4 matching sera from 24 anti JEV IgM negative (clinical encephalitis) patients were collected and tested for presence of JEV specific IgG by ELISA. Eighteen CSF samples and 8 matching sera from confirmed JE and 5 CSF samples and one matching serum from clinical encephalitis patients positive for JEV specific IgG were further assayed for subclass specificity using specific murine monoclonal antibodies. Almost all the samples exhibited IgG1 as the virus specific subclass. In addition to IgG1, one serum and one CSF sample each from two different confirmed JE patients showed the presence of virus specific IgG4 and IgG3 respectively. Half of the confirmed JE and clinical encephalitis patients exhibited intrathecal synthesis as evident from either elevated IgG index or CSF IgG/CSF albumin ratio. Most of the patients who recovered had predominantly virus specific IgG1 in CSF. It seems likely that IgG1 might have a protective role in clearance of virus from the central nervous system.en_US
dc.description.affiliationNational Institute of Virology, Pune.en_US
dc.identifier.citationThakare JP, Gore MM, Risbud AR, Banerjee K, Ghosh SN. Detection of virus specific IgG subclasses in Japanese encephalitis patients. Indian Journal of Medical Research. 1991 Sep; 93(): 271-6en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/20670
dc.language.isoengen_US
dc.source.urihttps://icmr.nic.in/ijmr/ijmr.htmen_US
dc.subject.meshAdolescenten_US
dc.subject.meshAdulten_US
dc.subject.meshAntibodies, Viral --cerebrospinal fluiden_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshDisease Outbreaksen_US
dc.subject.meshEncephalitis Virus, Japanese --immunologyen_US
dc.subject.meshEncephalitis, Japanese --epidemiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoglobulin G --cerebrospinal fluiden_US
dc.subject.meshIndia --epidemiologyen_US
dc.subject.meshMiddle Ageden_US
dc.titleDetection of virus specific IgG subclasses in Japanese encephalitis patients.en_US
dc.typeJournal Articleen_US
Files
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.79 KB
Format:
Plain Text
Description:
Download
Collections
Indian Journal of Medical Research