Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine.

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dc.contributor.authorGupta, M M
dc.contributor.authorPatel, Mitul G
dc.contributor.authorKedawat, Madhulika
dc.date.accessioned2014-05-19T05:54:16Z
dc.date.available2014-05-19T05:54:16Z
dc.date.issued2011-11
dc.description.abstractMotion sickness is a very common disturbance of the inner ear that is caused by repeated motion such as from the swell of the sea, the movement of a car, the motion of a plane in turbulent air, etc. Most medications for motion sickness need to be taken at least 30 minutes prior exposure to the activity that can cause the problem. This project is based on the hypothesis that Mouth Dissolving Films (MDF) are rapidly dissolving dosage forms which when placed in the mouth release the drug immediately. These dosage forms would be preferred by pediatric and geriatric patients since these are not associated with fear of choking. The fast dissolving films prepared by solvent casting method with suitable appearance, mechanical strength, peelability and disintegration time were obtained using Methocel E-5 as a primary film former. Meclizine HCl, a poorly water soluble and bitter drug could be successfully incorporated in the fast dissolving films with the help of solubilizers such as β-Cyclodextrine and PEG-400.en_US
dc.identifier.citationGupta M M, Patel Mitul G, Kedawat Madhulika. Enhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine. Journal of Applied Pharmaceutical Science. 2011 Nov; 1(9): 150-153.en_US
dc.identifier.urihttps://imsear.searo.who.int/handle/123456789/151007
dc.language.isoenen_US
dc.source.urihttps://www.japsonline.com/counter.php?aid=278en_US
dc.subjectMeclizine HClen_US
dc.subjectMethocel E-5en_US
dc.subjectβ-Cyclodextrineen_US
dc.subjectPEG-400en_US
dc.subjectSolvent Casting Methoden_US
dc.subjectMotion Sicknessen_US
dc.subjectMouth Dissolving Film (MDF)en_US
dc.titleEnhancement of dissolution rate of rapidly dissolving oral film of meclizine hydrochloride by complexation of Meclizine hydrochloride with ß-cyclodextrine.en_US
dc.typeArticleen_US
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