Assessment of telomerase as drug target in breast cancer
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Date
2020-05
Journal Title
Journal ISSN
Volume Title
Publisher
Indian Academy of Sciences
Abstract
Telomerase is a specialized enzyme which maintains telomere length at the extreme end of the chromosome.Over 90% of all cases of cancer show high expression of telomerase while in normal cells, its expression isextremely low or undetectable. Detection of telomerase activity in a wide range of breast cancer makestelomerase an interesting target for diagnosis and therapy. In this review, we have aimed to describe telomeraseas a therapeutic and accurate diagnostic target in breast cancer. Telomerase performs many extracurricularactivities apart from maintaining telomere length; here, we have also tried to address its role in epithelialmesenchymal transition (EMT) of breast cancer progression.
Description
Keywords
AZT, breast cancer, EMT, hTERT, TRAP assay
Citation
Jaiswal Rishi Kumar, Yadava Pramod Kumar. Assessment of telomerase as drug target in breast cancer. Journal of Biosciences. 2020 May; : 1-11